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Ebselen, um composto com propriedade insulino-mimética, reduz a hiperglicemia temporária induzida pelo diazinon em ratos
(Universidade Federal de Santa Maria, 2012-03-01)
The diazinon (DI) is a commonly organophosphorus (OP) used in pest control around the world. Severe acute
poisoning due to ingestion of OP in suicide attempts were reported during the past years. The main toxic effect
of ...
Estudo das alterações comportamentais e bioquímicas induzidas pela exposição ao Hg (II) sobre o sistema antioxidante e vias de sinalização celular em Drosophila melanogaster
(Universidade Federal de Santa Maria, 2012-03-16)
Mercury (Hg) consists in a heavy metal with toxicological relevance whose contamination
is mainly attributed to anthropogenic activities, leading to environmental contamination. It
is known that an induction in oxidative ...
Avaliação do potencial efeito antidepressivo do 2-BFI, ligante imidazolínico I2, em camundongos
(Universidade Federal de Santa Maria, 2012-03-02)
Depression is a complex, chronic and disabling psychiatric disease that carries
a high social cost. Among the various classes of antidepressants are the monoamine
oxidase A (MAO-A) inhibitors that reduce monoamine ...
Efeito antitumoral do extrato de carotenoides e biomassa de microalgas Scenedesmus obliquus em células de melanoma: envolvimento da sinalização purinérgica
(Universidade Federal de Santa Maria, 2023-05-19)
Cutaneous Melanoma (CM) is an aggressive and metastatic tumor, resulting in low
survival and high mortality rates. Despite significant advances in therapeutics, the disponible
drugs are often undefective and related to ...
Atividade de ectoenzimas purinérgicas após dano hepático crônico induzido por tioacetamida em ratos wistar e tratados com pentoxifilina
(Universidade Federal de Santa Maria, 2023-07-17)
The are innumerous hepatotoxic agents that can cause liver injury, but when this
damage extends for long periods, it can characterize a chronic profile that makes the
patient’s treatment and recuperation difficult. Chronic ...
Estudo dos efeitos induzidos por doses subletais do inseticida agrícola Tiametoxam sobre parâmetros bioquímicos e comportamentais de baratas da espécie Nauphoeta cinerea
(Universidade Federal de Santa Maria, 2023-09-29)
Thiamethoxam (TMX) is an agricultural insecticide belonging to the neonicotinoid
family. Its mechanism of action lies in the persistent activation of nicotinic acetylcholine
receptors (nAChR) in the nervous system of ...
Efeitos do resveratrol na sinalização purinérgica em camundongos expostos ao alumínio
(Universidade Federal de Santa Maria, 2023-09-12)
Aluminum (Al) is a compound found in nature, and is widely used industrially, which means that humans are exposed to it daily. Due to its ability to cross the blood-brain barrier, it can accumulate in the brain in regions ...
Efeito do exercício físico sobre o desenvolvimento de crises convulsivas pós-traumáticas em ratos: o papel da trombina
(Universidade Federal de Santa Maria, 2023-09-29)
Traumatic brain injury (TBI) affects about 69 million people worldwide and is the major cause
of post-traumatic epilepsy (PTE), a structural acquired type of epilepsy where acute seizures
onset can influence the ...
Caracterização do potencial genotóxico de porfirinas de base livre e metaloporfirinas de Zn (II)
(Universidade Federal de Santa Maria, 2023-09-06)
Photodynamic therapy (PDT) is a treatment with several benefits, such as few side
effects, ease of application and possible combination with other treatments. It is based on the
production of reactive oxygen species (ROS) ...
Avaliação fármaco-toxicológica da molécula JM-20 em Caenorhabditis elegans
(Universidade Federal de Santa Maria, 2023-10-17)
With the discovery of new molecules with pharmaceutical potential, studies examining different mechanisms of action and toxicological aspects emerge. The 3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido ...