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Atividade das enzimas purinérgicas e o uso de nanocápsulas de óleo de romã e silibinina no melanoma cutâneo
(Universidade Federal de Santa Maria, 2022-10-31)
Cancer is a multifactorial disease resulting from mutations in specific genes that cause cell
hyperproliferation. Currently, the most prevalent type of cancer is skin cancer, and its most
aggressive subtype is melanoma. ...
Desenvolvimento de métodos analíticos para determinação de impurezas em produtos farmacêuticos
(Universidade Federal de Santa Maria, 2019-03-12)
The presence of impurities in medicinal products is usually associated with their presence in the raw material and/or the production process of the drug itself. The presence of these impurities raises concern, not only ...
Avaliação das metodologias de detecção bacteriana e de resistência dos Staphylococcus coagulase negativa isolados das bolsas de concentrados plaquetários
(Universidade Federal de Santa Maria, 2015-05-22)
Platelet transfusion therapy has played an important role in the treatment of patients with hematological and oncological diseases. However, platelet transfusion represents a risk for bacterial sepsis. Platelet Concentrates ...
Avaliação da atividade biológica in vitro de triazenos, sertralina e metildopa como alternativas no reaproveitamento de medicamentos
(Universidade Federal de Santa Maria, 2021-04-19)
Currently, countless efforts to discover effective, selective and innovative antineoplastic and antimicrobial therapies have led to the synthesis and investigation of the biological activity of different molecules. Triazenes ...
Investigação da resistência bacteriana e avaliação de metodologias em isolados clínicos de Pseudomonas aeruginosa e Acinetobacter spp. de diferentes anos em um hospital universitário
(Universidade Federal de Santa Maria, 2017-04-28)
Pseudomonas aeruginosa and Acinetobacter spp. are microorganisms worldwide reported as pathogens of high prevalence in the etiology of nosocomial infections; they are opportunistic and have clinical importance in Health ...
Avaliação da atividade de enzimas que degradam nucleotídeos de adenina e do perfil oxidativo em ratos com sepse induzida
(Universidade Federal de Santa Maria, 2014-07-30)
Sepsis is recognized as a systemic inflammatory response (SIRS) to infection with the
presence of progressive tissue damage, where multiple organ failure is the most severe
expression. The purinergic signaling plays an ...
Avaliação do potencial citotóxico e antibacteriano in vitro de complexos triazenido e benzotriazenido-ona de Au(I) e Cu(II)
(Universidade Federal de Santa Maria, 2016-12-14)
Nowadays, the neoplastic diseases and bacterial infections caused by multidrug-resistant (MDR) microorganisms are ascending worldwide, representing great problems to public health. Thus, new antitumor and antimicrobial ...
Caracterização dos SCCmec e produção de biofilme em Staphylococcus aureus no Hospital Universitário de Santa Maria
(Universidade Federal de Santa Maria, 2017-08-11)
Staphylococcus aureus, in particular those resistant to methicillin (MRSA), are reported worldwide as pathogens of high prevalence in the etiology of infections. Its versatility as an important etiological agent results ...
Desenvolvimento de nanocápsulas peguiladas de risperidona em diferentes óleos: avaliação in vitro e in vivo
(Universidade Federal de Santa Maria, 2016-08-31)
This study aims to develop PEGylated nanocapsules containing Risperidone (RIS) in different oils and evaluate its performance in vivo and in vitro. The oils utilized for the results comparison were sesame (Ge), linseed ...
Desenvolvimento de uma formulação farmacêutica para uso tópico, análise fitoquímica e farmacológica de Persea americana Mill. (Lauraceae)
(Universidade Federal de Santa Maria, 2018-07-04)
The species Persea americana Mill., belonging to the Lauraceae family is known in popular
medicine as avocado. Several pharmacological effects attributed to this species have been
described in the ...