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O papel da amônia sobre as alterações comportamentais, neuroinflamação e apoptose em um modelo experimental de acidemia metilmalônica.
(Universidade Federal de Santa Maria, 2017-08-29)
Methylmalonic acidemia is an autosomal recessive metabolism biochemically characterized by
a deficiency in the activity of the mutase methylmalonyl-CoA and the tissue accumulation of
methylmalonate (MMA). In this acidemia, ...
Associação do polimorfismo MnSOD ALA16VAL com os biomarcadores inflamatórios, apoptóticos e BDNF em pacientes após acidente vascular encefálico tardio
(Universidade Federal de Santa Maria, 2017-07-01)
Stroke is one of the most frequent neurologic diseases and involves various risk factors such as atherosclerosis, dyslipidemia and diabetes mellitus. Furthermore, the mechanisms of action associated with the pathophysiology ...
Influência de Harpagophytum procumbens sobre parâmetros comportamentais e moleculares em um modelo de discinesia orofacial em ratos
(Universidade Federal de Santa Maria, 2017-02-18)
Fluphenazine is a typical antipsychotic used for the treatment of schizophrenia. However, its chronic use has been related to the appearance of extrapyramidal side effects, such as tardive dyskinesia (TD). Studies suggest ...
Potencial antidepressivo do extrato aquoso de Ilex paraguariensis em roedores: envolvimento do sistema monoaminérgico
(Universidade Federal de Santa Maria, 2017-03-31)
Ilex paraguariensis is a plant largely consumed in South America as an infusion known as ―chimarrão‖ or ―mate‖, which shows effects related to its action in the central nervous system. However, little is known about its ...
Gabapentina previne alterações comportamentais induzidas por anfetamina ou haloperidol em camundongos
(Universidade Federal de Santa Maria, 2017-12-19)
Schizophrenia is a chronic and highly complex psychiatric illness that manifests with a wide spectrum of changes that include cognitive, negative and positive symptoms. The drugs available for the treatment (antagonists ...
Efeito da atorvastatina sobre as alterações comportamentais, histológicas e bioquímicas em camundongos C57BL/6 com status epilepticus induzido por pilocarpina
(Universidade Federal de Santa Maria, 2017-03-06)
Epilepsy is a chronic neurological disease that affects 65 million people worldwide. Temporal
lobe epilepsy (TLE) is the most common type of focal epilepsy in adults, and also the one
with the highest refractoriness index ...
Efeitos, percepção de fármacos e comunicação química em peixes
(Universidade Federal de Santa Maria, 2017-06-08)
The presence of drugs in aquatic environments has been studied for decades and their actions have as consequence changes of several physiological mechanisms. It is known that there is a complex chemical communication between ...
Exposição a agroquímicos altera o funcionamento do eixo hipotálamo-hipófise-interrenal em zebrafish
(Universidade Federal de Santa Maria, 2017-08-21)
The increase of human occupation in rural areas and the intensification of agricultural practices produces increasingly agrochemical waste up to aquatic ecosystems. Based on this, many studies are needed to clarify the ...
Avaliação da Vanillosmopsis arborea Baker e (-)-α-bisabolol frente a parâmetros oxidativos e toxicológicos
(Universidade Federal de Santa Maria, 2017-08-18)
Vanillosmopsis arborea Baker belongs to the Asteraceae family and has a recognized economic value due to its anti-inflammatory properties, derived from sesquiterpene (-)-α-bisabolol (BISA), which is present in high ...
A ação anti-inflamatória do lítio é influenciada por fatores genéticos, nutricionais e fármacos antidepressivos: estudos in vitro
(Universidade Federal de Santa Maria, 2017-09-01)
Population aging has increased the prevalence of chronic non-communicable diseases, including psychiatric disorders such as depression and bipolar spectrum disorders (BSDs). Evidence suggests that such disorders are ...