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Triazenos: clivagem do DNA, atividade antibacteriana e toxicidade frente à Artemia salina Leach
(Universidade Federal de Santa Maria, 2007-12-13)
In this work, six triazene compounds are assayed to DNA cleavage activity. The same six triazenes and the drug Asercit® (dacarbazine) are assayed to antibacterial activity and toxicity to Artemia salina Leach.: ...
Desenvolvimento e validação de metodologias para avaliação de ezetimiba por cromatografia líquida e espectrometria de massas
(Universidade Federal de Santa Maria, 2007-03-30)
Ezetimibe selectively inhibits the intestinal absorption of dietary cholesterol and related plant sterols, from the 2-azetidinones group, and is used for the treatment of
hypercholesterolemia and phytosterolemia. The ...
Alterações do gene TP53 na mucosa esofágica de pacientes com carcinoma epidermóide do esôfago
(Universidade Federal de Santa Maria, 2016-08-22)
Esophageal cancer is a tumor with a higher incidence in males, and it is highly fatal. Epidemiological
data points out to consumption of tobacco and alcohol and the exposition to polycyclic aromatic
hydrocarbon are the ...
Estudo de métodos cromatográficos para avaliação de potência de filgrastima e correlação com ensaio biológico
(Universidade Federal de Santa Maria, 2006-06-23)
The granulocyte-colony stimulating factor (G-CSF) is a hematopoietic cytokine that stimulates and regulates the proliferation and differentiation of neutrophil precursor cells of the bone marrow. The recombinant hormone ...
Identificação e caracterização molecular de Echinococcus granulosus sensu lato em suinos no Rio Grande do Sul
(Universidade Federal de Santa Maria, 2013-03-01)
Echinococcosis is a zoonotic infection caused by a metacestóide belonging to the family Taeniidae genus Echinococcus. The larval stage (hydatid cyst) of the parasite causes serious public health problems, and achieves ...
Bezafibrato: validação de metodologia e aplicação em estudo farmacocinético de formulações farmacêuticas
(Universidade Federal de Santa Maria, 2007-10-11)
Fibrates constitute an important class of drugs used in the treatment of the
dyslipidemia, which is the main risk factor for the aterosclerosis development and
incidence of cardiovascular diseases. The present dissertation ...
Caracterização de extratos de Connarus perrottetii var. angustifolius Radlk e avaliação do comportamento antioxidante frente a espécies radicalares
(Universidade Federal de Santa Maria, 2013-07-31)
This paper describes the development of methodology for capillary electrophoresis with UV detection for the determination of 14 polyphenolic antioxidants in extracts of Connarus perrottetii var. angustifolius Radlk, a ...
Farmacobotânica, atividade antiinflamatória e parâmetros bioquímicos de Nopalea cochenillifera (L.) Salm-Dick (Cactaceae)
(Universidade Federal de Santa Maria, 2011-03-14)
The family Cactaceae comprises about 1900 species in 125 genera. Nopalea cochenillifera (L.) Salm-Dyck
occurs from Mexico to Panama and has been adapted in several countries. It is a shrubby plant that reaches 3-4
m tall, ...
Atividade de enzimas que degradam nucleotídeos e nucleosídeo de adenina em plaquetas de pacientes com tireoidite de Hashimoto em tratamento com levotiroxina sódica
(Universidade Federal de Santa Maria, 2012-07-18)
Hashimoto Thyroiditis (HT) or chronic lymphocytic thyroiditis is an autoimmune disease that causes the destruction of the thyroid gland by inflammatory infiltrates and consequently loss of function. This disease is spread ...
Suscetibilidade in vitro de Sporothrix schenckii e avaliação da antifungicoterapia na esporotricose experimental em modelo murino
(Universidade Federal de Santa Maria, 2008-03-19)
The approval of the protocol M-38A by Clinical and Laboratory Standards Institute
(CLSI), which established standardized procedures for the evaluation of the in vitro
susceptibility of moulds, has expanded the inherent ...