Buscar
Itens para a visualização no momento 1-10 of 13
Desenvolvimento de nanocarreadores a base de piperina: influência do polímero e citotoxicidade in vitro – in vivo
(Universidade Federal de Santa Maria, 2016-12-16)
This study aimed the development of nanoemultions and polymeric nanocapsule suspensions containing
piperine, in order to study their considering photodegradation and citotoxicity. To quantify piperine at the
nanostructures, ...
Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de rivaroxabana
(Universidade Federal de Santa Maria, 2015-02-27)
Rivaroxaban is an oral anticoagulant drug indicated for deep venous thromboembolism prophylaxis. A reversed-phase liquid chromatography (RP-LC) method was developed and validated for the determination of rivaroxaban in ...
Buddleja thyrsoides Lam.: estudo morfoanatômico, fitoquímico e biológico
(Universidade Federal de Santa Maria, 2007-12-19)
The Scrophulariaceae family is composed of some 25 genera and more than 1200 species.
The genus Buddleja, widely distributed around the world, belongs to this family presently.
Buddleja thyrsoides Lam. species, object ...
Correlação entre citotoxicidade, alterações cromossômicas e atividade antibacteriana de compostos triazenos em células de medula óssea
(Universidade Federal de Santa Maria, 2013-08-23)
Leukemias are a heterogeneous group of hematologic malignancies. The treatment of these neoplasms has been a challenge to the scientific community due to genetic diversity in leukemic cells. Acquired chromosomal abnormalities ...
Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de febuxostate
(Universidade Federal de Santa Maria, 2013-07-25)
Febuxostat is a novel non purine drug indicated for the treatment of hyperuricemia in gout. A reversed-phase liquid chromatography (RP-LC) method was validated for the determination of febuxostat in pharmaceutical dosage ...
Extratos de folhas e sementes de Syzygium cumini (L.) Skeels protegem os linfócitos do dano oxidativo
(Universidade Federal de Santa Maria, 2017-01-20)
The use of medicinal plants for the purpose of treatment / prevention of diseases is common practice among the population, and has been associated with a lower risk for the development of several pathologies. Among these ...
Desenvolvimento de nanopartículas poliméricas de Eudragit® RL 100 contendo tioconazol para tratamento de doença fúngica ocular
(Universidade Federal de Santa Maria, 2020-07-03)
The human eye, due to its unique structure and continuous exposure to the external environment, becomes susceptible to contamination by several pathogenic microorganisms, among which are fungi. In this way, the eye defence ...
Desenvolvimento de sistemas nanoestruturados à base de óleo de pracaxi contendo ubiquinona e avaliação da citotoxicidade in vitro
(Universidade Federal de Santa Maria, 2014-03-27)
This work aimed the preparation of novel nanocapsules and nanoemulsions based on pracaxy oil loaded with ubiquinone. For nanocapsules, poly(-caprolactone) (PCL) or Eudragit® EPO were employed in the preparation. For ...
Avaliação da atividade citotóxica e antibacteriana de um composto triazenido complexado com íon ouro (I)
(Universidade Federal de Santa Maria, 2015-05-15)
Cancer represents one of the leading causes of death worldwide and efforts to discover more effective anticancer therapies have led to the synthesis of a wide diversity of molecular species. Another major challenge is the ...
Avaliação da atividade biológica de triazenos inéditos complexados com Au(I)
(Universidade Federal de Santa Maria, 2013-03-22)
The Triazenes are compounds with proven antibacterial and cytotoxic activity.
Variations in the chemical structure such as complexation with metals like gold (I) can confer
different biological activities. The antineoplastic ...