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Desenvolvimento de nanocápsulas para a liberação controlada de crisina: avaliação da atividade antioxidante e da citotoxicidade in vitro
(Universidade Federal de Santa Maria, 2015-09-25)
Chrysin (5,7-dihydroxyflavone) is a flavonoid (class of flavones), which presents antioxidant and antitumoral activities. However, it has low solubility and hence its bioavailability in the body is low, limiting its ...
Desenvolvimento de nanocápsulas poliméricas para liberação pulmonar do dipropionato de beclometasona
(Universidade Federal de Santa Maria, 2013-03-22)
Polymeric nanocapsules have been studied extensively for drug delivery by various routes of administration. Currently, the nanoencapsulation of drugs is considered the most efficient means of ensuring controlled release, ...
Desenvolvimento tecnológico de produtos secos redispersíveis a partir de nanoestruturas contendo tioconazol
(Universidade Federal de Santa Maria, 2013-04-29)
Spray-drying and freeze-drying are dehydration techniques which serve as alternative to increase the stability of formulations which are in aqueous medium. Therefore, this study objectived the development of redispersible ...
Sistemas nanoestruturados contendo óleo essencial de Melaleuca alternifolia: desenvolvimento de formulações e atividade biológica
(Universidade Federal de Santa Maria, 2011-08-15)
The aim of this work was the development of nanostructured formulations containing
M. alternifolia essential oil. Polymeric nanocapsules and nanoemulsions (10 mg/mL) were
prepared by the interfacial deposition of preformed ...
Desenvolvimento tecnológico de suspensões e liofilizados de nanocápsulas poliméricas para a veiculação do neuroprotetor idebenona
(Universidade Federal de Santa Maria, 2013-10-30)
Idebenone is an antioxidant, a synthetic derivative of coenzyme Q10, with several applications, such as neuroprotection. However, this drug has low solubility in water, besides is irritant substance and has chemical ...
Formulações nanoestruturadas contendo rutina: desenvolvimento, atividade antioxidante in vitro e efeito sobre a cicatrização cutânea
(Universidade Federal de Santa Maria, 2010-08-16)
This work had as main objective the development of nanostructured formulations
containing rutin, using nanoparticles prepared with alternative vegetables oils. In the first chapter
it was demonstrated the feasibility of ...
Desenvolvimento tecnológico de nanocápsulas para a liberação controlada do neuroprotetor vimpocetina
(Universidade Federal de Santa Maria, 2015-05-27)
The Vinpocetine is a synthetic derivative of the vincamine alkaloid, which has a significant neuroprotective effect and is used in the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's, as well ...
Formulações nanoestruturadas contendo a associação coenzima Q10 e vitamina e acetato: desenvolvimento e avaliação de atividades biológicas
(Universidade Federal de Santa Maria, 2016-03-28)
Coenzyme Q10 is an endogenous synthesized molecule that presents antioxidant activity and
acts on cellular respiration process and ATP synthesis. Besides, it presents neuroprotective
effect, anti-inflammatory and ...
Desenvolvimento de nanopartículas poliméricas de Eudragit® RL 100 contendo tioconazol para tratamento de doença fúngica ocular
(Universidade Federal de Santa Maria, 2020-07-03)
The human eye, due to its unique structure and continuous exposure to the external environment, becomes susceptible to contamination by several pathogenic microorganisms, among which are fungi. In this way, the eye defence ...
Desenvolvimento de sistemas nanoestruturados à base de óleo de pracaxi contendo ubiquinona e avaliação da citotoxicidade in vitro
(Universidade Federal de Santa Maria, 2014-03-27)
This work aimed the preparation of novel nanocapsules and nanoemulsions based on pracaxy oil loaded with ubiquinone. For nanocapsules, poly(-caprolactone) (PCL) or Eudragit® EPO were employed in the preparation. For ...