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Detecção de mecanismos de resistência, propriedades adesivas e capacidade de formação de biofilmes de Klebsiella pneumoniae multirresistentes
(Universidade Federal de Santa Maria, 2013-03-28)
During the last decades, K. pneumoniae has emerged as one of the most clinically significant pathogens, especially due to the high prevalence of strains producing extended spectrum β-lactamases (ESBL) and carbapenemases. ...
Validação de método cromatográfico por exclusão molecular para avaliação de interferon-alfa2a e estudos de correlação
(Universidade Federal de Santa Maria, 2010-09-30)
Human interferon-α2a (hIFN-α2a) is a natural protein produced by the cells of the immune system with antiviral, antiproliferative and immunomodulatory properties. A size exclusion liquid chromatography (SE-LC) method was ...
Epidemiologia e investigação de mecanismos de resistência aos carbapenêmicos e polimixinas em bacilos gram-negativos multirresistentes
(Universidade Federal de Santa Maria, 2018-09-28)
Bacterial resistance is a global public health problem and leads to relapsing nosocomial infections, high morbidity and mortality rates and high financial impact. Carbapenems and polymyxins are extensively antimicrobials ...
Caracterização molecular de enterobactérias resistentes aos carbapenêmicos
(Universidade Federal de Santa Maria, 2014-04-30)
Enterobacteriaceae resistant to carbapenems cause great impact on public health due to their different evolutionary mechanisms of resistance. The mechanism of resistance that recently has been reported in Enterobacteriaceae ...
Investigação da presença e migração de metais presentes em estabilizantes e catalisadores em embalagens plásticas
(Universidade Federal de Santa Maria, 2015-03-16)
The polyvinyl chloride (PVC) and polyethylene terephthalate (PET) polymers are widely used throughout the world. Different types of compounds are used in the polymer synthesis and to improve their properties. In the case ...
Ação antinociceptiva e anti-inflamatória da fração acetato de etila da casca da Scutia buxifolia Reiss em camundongos
(Universidade Federal de Santa Maria, 2016-02-12)
Pain and inflammation are physiological processes, which when persist can be harmful to health. The pain when improperly or left untreated can become chronic pain. Moreover, the inflammation can be involved in the pathogenesis ...
Desenvolvimento de nanocarreadores a base de piperina: influência do polímero e citotoxicidade in vitro – in vivo
(Universidade Federal de Santa Maria, 2016-12-16)
This study aimed the development of nanoemultions and polymeric nanocapsule suspensions containing
piperine, in order to study their considering photodegradation and citotoxicity. To quantify piperine at the
nanostructures, ...
Desenvolvimento de nanocápsulas poliméricas contendo Indol-3-Carbinol e avaliação biológica das formulações
(Universidade Federal de Santa Maria, 2016-08-08)
Indole-3carbinol (I3C) is a phytochemical that has several therapeutic properties. However, it is unstable
against acid and light conditions. In this sense, polymeric nanocapsules are interesting alternatives for
the ...
Desenvolvimento e avaliação biológica in vitro de nanopartículas poliméricas ph-sensíveis contendo metotrexato
(Universidade Federal de Santa Maria, 2017-09-01)
The traditional cancer treatments act in a non-specific way, and cause side effects through loss of normal cell functions. Therefore, the development of new treatments with greater selectivity for the tumoral tissue is ...
Análise fitoquímica e atividade farmacológica in vitro e in vivo de Schinus molle L.
(Universidade Federal de Santa Maria, 2019-08-27)
The species S. molle L. is widely distributed in Rio Grande do Sul. The aerial
parts of S. molle are popularly used for different therapeutic purposes as antiinflammatory,
anti-haemorrhagic, antiseptic, mild laxative, ...