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Detecção de mecanismos de resistência, propriedades adesivas e capacidade de formação de biofilmes de Klebsiella pneumoniae multirresistentes
(Universidade Federal de Santa Maria, 2013-03-28)
During the last decades, K. pneumoniae has emerged as one of the most clinically significant pathogens, especially due to the high prevalence of strains producing extended spectrum β-lactamases (ESBL) and carbapenemases. ...
Validação de método cromatográfico por exclusão molecular para avaliação de interferon-alfa2a e estudos de correlação
(Universidade Federal de Santa Maria, 2010-09-30)
Human interferon-α2a (hIFN-α2a) is a natural protein produced by the cells of the immune system with antiviral, antiproliferative and immunomodulatory properties. A size exclusion liquid chromatography (SE-LC) method was ...
Indicadores Biológicos de Exposição a solventes orgânicos e sua inter-relação com o estresse oxidativo
(Universidade Federal de Santa Maria, 2008-04-16)
The use of organic solvents in the work environment represents a significant risk to workers health. The painters composed, among others, a group of individuals who are in direct contact with solvents through the respiratory ...
Identificação de metalo-β-lactamases em bacilos gram-negativos não fermentadores isolados no Hospital Universitário de Santa Maria
(Universidade Federal de Santa Maria, 2008-01-18)
In recent years, the isolation of bacteria producing β-lactamases has caused concern around the world, due to the fact these enzymes hydrolysis the ring β-lactam antimicrobials used in the main clinic. This aim of this ...
Epidemiologia e investigação de mecanismos de resistência aos carbapenêmicos e polimixinas em bacilos gram-negativos multirresistentes
(Universidade Federal de Santa Maria, 2018-09-28)
Bacterial resistance is a global public health problem and leads to relapsing nosocomial infections, high morbidity and mortality rates and high financial impact. Carbapenems and polymyxins are extensively antimicrobials ...
Efeitos da radiação ionizante na maturação de oócitos bovinos: busca por modelos de estudo em radiobiologia
(Universidade Federal de Santa Maria, 2015-08-21)
The medical application of ionizing radiation in radiotherapy has been crucial in the treatment
of cancer due to its harmful action tumor cells, by direct interaction with DNA molecules or indirectly
with the H2O molecules ...
Desenvolvimento de nanoemulsões de óleo de romã contendo ou não cetoprofeno: avaliação da atividade antitumoral e antinociceptiva
(Universidade Federal de Santa Maria, 2014-10-03)
This study aimed to prepare nanoemulsions of pomegranate seed oil, containing or not
ketoprofen, and to evaluate antitumor and antinociceptive activity. First, pomegranate seed oil
nanoemulsions were prepared by spontaneous ...
Ebastina: obtenção de novas formas cristalinas e caracterização no estado sólido
(Universidade Federal de Santa Maria, 2015-12-04)
Ebastine (EBA) is a second-generation antihistamine with poor water solubility. It is used in the treatment of allergic rhinitis and chronic idiopathic urticaria. For oral administration of drugs, there is a preference for ...
Características genotípicas e fenotípicas de cepas de Escherichia coli isoladas de carne moída bovina in natura
(Universidade Federal de Santa Maria, 2016-01-15)
Escherichia coli is a bacterium that comprise the normal intestinal flora of warm-blooded
animals, responsible for a variety of diseases in humans, as bacteremia, urinary tract and
intestinal infections. Some become ...
Caracterização molecular de enterobactérias resistentes aos carbapenêmicos
(Universidade Federal de Santa Maria, 2014-04-30)
Enterobacteriaceae resistant to carbapenems cause great impact on public health due to their different evolutionary mechanisms of resistance. The mechanism of resistance that recently has been reported in Enterobacteriaceae ...