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Avaliação de potência/teor de toxina botulínica tipo a por métodos cromatográficos e bioensaios
(Universidade Federal de Santa Maria, 2018-07-24)
The botulinum toxin type A is one of the seven different serotypes of toxins produced by fermentation process with Clostridium botulinum, under anaerobic conditions. Biotechnological product has been used in therapeutic ...
Desenvolvimento e validação de métodos cromatográficos para avaliação de teor/potência de insulina glargina
(Universidade Federal de Santa Maria, 2016-03-30)
hans, and is secreted into the bloodstream. It plays and important role in regulating the
metabolic activities of the body, particularly the homeostasis of the blood glucose. Insulin
glargine is a recombinant human insulin ...
Estudo de métodos cromatográficos e ensaio biológico para avaliação do anticorpo monoclonal denosumabe
(Universidade Federal de Santa Maria, 2017-07-27)
Denosumab (DmAb) is a fully human monoclonal antibody that inhibits osteoclast formation, function and survival, reducing bone turnover and resorption. Structurally, it is a fully human immunoglobulin G2, yielding a molecular ...
Avaliação de potência de interferon beta -1b por métodos cromatográficos validados e bioensaio
(Universidade Federal de Santa Maria, 2017-07-27)
Interferon is a cytokine with antiviral, antiproliferative and immunomodulatory properties that influences cell metabolism, growth and differentiation. The recombinant human interferon β 1b (rhIFNβ-1b) is a non-glycosylated ...
Validação de métodos cromatográficos para avaliação de estreptoquinase e correlação com o bioensaio
(Universidade Federal de Santa Maria, 2016-03-30)
The streptokinase (STK) is a secreted and isolated molecule of β-hemolytic streptococci,
consists of 414 amino acids and clinically indicated as a thrombolytic agent for myocardial
infarction, deep vein thrombosis, ...
Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de rivaroxabana
(Universidade Federal de Santa Maria, 2015-02-27)
Rivaroxaban is an oral anticoagulant drug indicated for deep venous thromboembolism prophylaxis. A reversed-phase liquid chromatography (RP-LC) method was developed and validated for the determination of rivaroxaban in ...
Desenvolvimento e validação de método por cromatografia líquida em fase reversa para análise de febuxostate
(Universidade Federal de Santa Maria, 2013-07-25)
Febuxostat is a novel non purine drug indicated for the treatment of hyperuricemia in gout. A reversed-phase liquid chromatography (RP-LC) method was validated for the determination of febuxostat in pharmaceutical dosage ...
Desenvolvimento e validação de métodos analíticos para controle de qualidade de comprimidos de empagliflozina e estudo preliminar de estabilidade
(Universidade Federal de Santa Maria, 2018-03-27)
Diabetes mellitus (DM) is a disease characterized by a heterogeneous group of metabolic disorders, which present hyperglycemia in common. Different classes of oral antidiabetics, such as empagliflozin, belonging to the ...
Desenvolvimento analítico, estudos de permeação cutânea e potencial de irritação ocular de formulações de repelentes à base de N',N'-dietil-m-toluamida
(Universidade Federal de Santa Maria, 2019-01-10)
N ', N'-diethyl-m-toluamide (DEET) is the most commonly repellent used against mosquito
vectors of diseases such as dengue, yellow fever and chikungunya. In Brazil, DEET is found
on the market in aerosol, solution, lotion ...
Desenvolvimento e validação de metodologia analítica para avaliação de alisquireno em formulação farmacêutica
(Universidade Federal de Santa Maria, 2010-08-13)
Aliskiren is the first representative of a new class of drugs, the low molecular weight renin inhibitors, orally active and clinically used in a new effective treatment for hypertension. In the present study, the methods ...