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Desenvolvimento e validação de método por cromatografia líquida em fase reversa para avaliação de interleucina-11 humana recombinante. Correlação com o bioensaio
(Universidade Federal de Santa Maria, 2011-07-28)
Interleukin 11 (IL-11) is a multifunctional cytokine in the IL-6 type family of long-chain
helical cytokines, which modulates the proliferation, differentiation and maturation of various types of
hematopoietic cells. ...
Desenvolvimento e validação de metodologia para análise de valdecoxibe. Avaliação de efeitos sobre parâmetros hematológicos
(Universidade Federal de Santa Maria, 2006-06-01)
Valdecoxib is a non-steroidal anti-inflammatory drug that represents a second-generation of cyclooxygenase-2 enzyme inhibitor and possesses anti-inflammatory, analgesic and antipyretic activities. In this work a reversed-phase ...
Desenvolvimento e validação de métodos cromatográficos para avaliação de interferon-alfa 2a em formulações farmacêuticas
(Universidade Federal de Santa Maria, 2009-03-17)
The interferon is a cytokine with antiviral, antiproliferative, and immunomodulatory
properties. It is a protein synthesized by cells in response to viral infection, producing successive
biochemistry alterations. The ...
Avaliação de potência de toxina botulínica tipo a por ensaios biológicos e método por cromatografia líquida em fase reversa
(Universidade Federal de Santa Maria, 2015-02-26)
Botulinum toxin type A (BTTA) is a polypeptide with 1296 amino acids and its used in some pathologies like hyperhidrosis and migraine, but the cosmetic area is the most important application. BTTA is produced from broth-culture ...
Avaliação do fibrinogênio como uma nova fonte para a formação in vitro de produtos proteicos de oxidação avançada
(Universidade Federal de Santa Maria, 2015-07-08)
Oxidative stress is characterized by an imbalance between the production of free radicals, particularly reactive oxygen species (ROS), and the defense capacity of the organism against these species, leading to a progressive ...
Atividade da delta aminolevulinato desidratase sangüínea e o estresse oxidativo em pacientes hemodialisados
(Universidade Federal de Santa Maria, 2007-03-09)
The acid aminolevulinato dehydratase (δ-ALA-D) is a thiol enzyme involved in tetrapirrólicos composite biosynthesis, as heme. This enzyme is inhibited by some metals, having been also its inhibition a pointer of poisoning ...
Avaliação da influência do óleo e do polímero sobre as características físico-químicas e estabilidade de sistemas nanoestruturados contendo ubiquinona
(Universidade Federal de Santa Maria, 2014-03-31)
This work evaluated the influence of the composition on the physico-chemical characteristics, stability and photostability of nanostructures containing ubiquinone. Nanocapsules (NC) and nanoemulsions (NE) were prepared by ...
Análise de estimulantes em suplementos alimentares e produtos naturais a base de plantas comercializados para fins de emagrecimento no Brasil
(Universidade Federal de Santa Maria, 2015-02-27)
The strong advertising appeal, the search for a good physique, and the improvement in
physical performance, has risen the popularity of food supplements and other therapies with
slimming supplements based on plant extracts. ...
Estudo fitoquímico e de toxicidade (aguda e subaguda) de Celtis iguanaea (Jacq.) Sarg. em ratos Wistar
(Universidade Federal de Santa Maria, 2015-03-27)
The Celtis iguanaea species is popularly known as esporão-de-galo and its leaves are used in folk medicine to treat body aches, rheumatism, asthma, colic, indigestion, ulcers, and as a diuretic, and roots for urinary ...
Glechon spathulata Benth. (Lamiaceae) compostos fenólicos e atividade biológica
(Universidade Federal de Santa Maria, 2016-08-31)
Glechon spathulata Bentham, belonging to the Lamiaceae family, is known as manjerona-do-campo, has its leaves used popularly as culinary flavoring, diaphoretic, stomachic in dyspepsia, antiseptic and expectorant in catarrhal ...