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Desenvolvimento de suspensões e granulados nanotecnológicos contendo o antioxidante hidrofílico pirroloquinolina quinona
(Universidade Federal de Santa Maria, 2017-10-25)
Pyrroloquinoline quinone (PQQ) is a naturally occurring hydrophilic o-quinone which has shown different biological activities, as potent antioxidant activity. In order to improve its pharmacological performance and to ...
Desenvolvimento de hidrogéis mucoadesivos contendo nanocápsulas catiônicas de clotrimazol para o tratamento da candidíase vulvovaginal
(Universidade Federal de Santa Maria, 2015-03-16)
This study aimed the development of a novel formulation for the treatment of vulvovaginal candidiasis. Polymeric nanocapsules of Eudragit® RS100 were used as a clotrimazole carrier system and evaluated for their mucoadhesive ...
Atividade do óleo de Cymbopogon flexuosus livre e nanoestruturado frente a micobactérias de crescimento rápido
(Universidade Federal de Santa Maria, 2018-02-28)
Rapidly Growing Mycobacteria (RGM) are emerging pathogens responsible for various
human infections, although they are often considered only as contaminants or colonizers. The
formation of biofilms by these ...
Suscetibilidade de trichophyton rubrum e trichophyton mentagrophytes frente a agentes antifúngicos
(Universidade Federal de Santa Maria, 2015-05-29)
Dermatophytes are a group of fungi with the capacity to invade keratinized tissues and cause infections called dermatophytosis. They are common worldwide, and does not know the true incidence because it is not notifiable. ...
Reposicionamento dos antidepressivos e avaliação da atividade antibacteriana e de nuclease química in vitro de oxalato de escitalopram e clonazepam
(Universidade Federal de Santa Maria, 2019-08-22)
The emergence of multiresistance to commercially available antimicrobials today is likely to
continue to be one of the major global public health problems, as it has worrying clinical and
economic consequences. Concomitant ...
Atividade antimicrobiana do óleo essencial de camomila romana (Chamaemelum nobile)
(Universidade Federal de Santa Maria, 2019-03-11)
The increased prevalence of infections by multiresistant microorganisms has drawn
the attention of the scientific community to the need for new antimicrobial drugs. At the
same time, the perception of the inevitability ...
Desenvolvimento de nanocápsulas poliméricas com diferentes revestimentos para a liberação cerebral de vimpocetina
(Universidade Federal de Santa Maria, 2018-02-02)
Vinpocetine (VP) is used in neurodegenerative diseases, and researches have
indicated a promising anticonvulsant effect of this drug. However, it shows some limitations as
low aqueous solubility and short half-life. ...
Desenvolvimento de sistemas microparticulados a partir da blenda Eudragit® L100 e goma gelana para liberação oral de cetoprofeno
(Universidade Federal de Santa Maria, 2017-08-30)
Ketoprofen is a non-steroidal anti-inflammatory drug with analgesic and antipyretic properties. However, this drug has a short half-life, and causes adverse effects on the gastrointestinal tract by limiting its application ...
Avaliação anti-inflamatória e antioxidante do extrato de tucumã (Astrocaryum aculeatum): estudos in vitro e in vivo
(Universidade Federal de Santa Maria, 2018-01-19)
With the rise of new concepts such as functional foods, nutraceuticals and phytomedicines, allied to the use of traditional medicine, products of plant origin are in evidence. Brazil is a highlight in the development of ...
Avaliação de métodos na produção de biofilme em Staphylococcus spp. isolados de hemoculturas de unidade de terapia intensiva adulta
(Universidade Federal de Santa Maria, 2017-09-27)
Intensive Care Units (ICUs) are intended for the care of critically ill patients who need continuous monitoring and support of their vital functions. These are 5 to 10 times more likely to contract with Bloodstream Infections, ...