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Efeitos anti-nociceptivo e anti-edematogênico da glibenclamida em um modelo de gota aguda em ratos
(Universidade Federal de Santa Maria, 2013-02-23)
Gout is one form of inflammatory arthritis, which is caused by the precipitation of crystals of monosodium urate (MSU) in the joints. Acute gout is associated with sudden and painful inflammatory episodes characterized by ...
Mecanismos de captação e toxicidade do metilmercúrio: Envolvimento do sistema glutamatérgico e do cálcio em fatias e mitocôndrias de ratos.
(Universidade Federal de Santa Maria, 2012-01-22)
Methylmercury (MeHg) is a highly toxic environmental contaminant that can be accumulated on several tissues, inducing cellular dysfunction on various organs, especially in the central nervous system (CNS). The mechanisms ...
Efeito do tipo antidepressivo do 7-flúor-1,3-difenilisoquinolina-1-amina em modelos de estresse em roedores
(Universidade Federal de Santa Maria, 2018-03-23)
Current treatments for depression are inadequate for many patients and progress in understanding of this psychiatric disease is slow. The isoquinoline is an important class of molecules with antidepressant-like effect in ...
O sistema opioide contribui para o efeito do tipo antidepressivo do disseleneto de m-trifluormetil-difenila em camundongos
(Universidade Federal de Santa Maria, 2018-07-20)
Depression is a mental disorder with complex pathophysiology and characterized by multiple symptoms, which makes it difficult to treat this disease. In the last decades, the opioid system has become the focus of depression ...
Consumo de mel fornece proteção contra alterações motoras e moleculares induzidas por hipóxia/reperfusão em Drosophila melanogaster
(Universidade Federal de Santa Maria, 2017-02-14)
Honey is a complex product produced by honeybees from nectar, being widely used for its sweetening properties, as well as for its benefits to human health. Honey presents anti-inflammatory, hypoglycemic and antioxidant ...
Papel do sistema purinérgico no lúpus eritematoso sistêmico: um estudo clínico e de revisão
(Universidade Federal de Santa Maria, 2018-12-18)
Systemic Lupus Erythematosus (SLE) is a multifactorial inflammatory autoimmune disease caused by an immune dysfunction characterized by a breakdown of immune self-tolerance, activation of autoreactive T lymphocytes and B ...
Efeito de compostos naturais no envelhecimento e em modelos de doença de Alzheimer no nematódeo Caernorhabditis elegans
(Universidade Federal de Santa Maria, 2018-09-05)
During ageing, the cell repair system, including adaptative response to oxidative stress and unfolded protein degradation. In last decades, the increasing life expectancy, added to genetic and ambiental factors, has ...
Identificação dos mecanismos entomotoxicos de dois compostos inseticidas naturais em modelo experimental alternativo de insetos: extrato contendo anatoxina-a(s) e jaburetox
(Universidade Federal de Santa Maria, 2019-03-29)
The risk assessment is a stage that aims at the evaluation and characterization of the toxic properties of xenobiotic compounds, conditions of exposure to humans and the environment. The aim of this work was to contribute ...
Potencial tóxico e anticarcinogênico da alga Prasiola crispa
(Universidade Federal de Santa Maria, 2015-12-22)
Toxic and anticarcinogenic effects of Prasiola Seaweed extract crispa (PCE) were investigated in Drosophila melanogaster, Nauphoeta cinérea and leukemic cells. In fruit flies, toxicity was assessed as mortality and biochemical ...
Avaliação da ação anorexígena do 4, 4’-dicloro difenil disseleneto em ratos
(Universidade Federal de Santa Maria, 2015-04-30)
Obesity is an ever-increasing health concern of global importance. Despite that, treatment options remain limited leading to a constant search for therapies well tolerated and efficacious. Based on several biological actions ...