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Itens para a visualização no momento 81-90 of 153
Avaliação do potencial terapêutico do extrato aquoso de Peumus boldus (boldo) frente à toxicidade induzida por ferro e cobre em diferentes modelos experimentais
(Universidade Federal de Santa Maria, 2018-08-10)
The transition metals iron (Fe2+) and copper (Cu2+) are vital trace elements due to oxi-reducing
properties. However, the free Fe2+ and Cu2+ accumulation can lead to oxidative stress (OS), by catalisis
the Fenton reaction. ...
Dieta suplementada com disseleneto de difenila atenua as alterações bioquímicas e comportamentais no modelo de hipotireoidismo induzido por metimazol
(Universidade Federal de Santa Maria, 2012-12-14)
Hypothyroidism is a syndrome resulting from decreased production and secretion of triiothyronine (T3) and thyroxine (T4) hormones, frequently diagnosed in women. Clinical and experimental evidence support the association ...
ATP como modulador do sistema purinérgico e inflamação e status redox em pacientes com melanoma
(Universidade Federal de Santa Maria, 2019-09-16)
Melanoma is a type of skin cancer, formed in melanocytes, cells that produce the pigment melanin. The melanocytes of the epidermis are the most common places of melanoma’s origin; however, it can be also developed in ...
Camundongos infectados experimentalmente com Trypanosoma cruzi: efeito da doença de chagas sobre as enzimas purinérgicas e testes de um novo protocolo tripanocida
(Universidade Federal de Santa Maria, 2018-02-09)
Chagas disease is a zoonosis caused by Trypanosoma cruzi. It occurs primarily in Latin America, where it causes serious health problems for about 7 million people in endemic regions. Considering that Chagas disease currently ...
Envolvimento do estresse oxidativo e dos sistemas colinérgico e purinérgico na esclerose múltipla: estudo clínico e de revisão
(Universidade Federal de Santa Maria, 2018-02-23)
Multiple sclerosis (MS) is one of the main chronic inflammatory diseases of the central nervous system
(CNS) that cause functional disability in young adults. It is considered one complex autoimmune and
neurodegenerative ...
Avaliação do efeito do ácido cafeico em linhagem celular de melanoma cutâneo
(Universidade Federal de Santa Maria, 2019-10-11)
Cutaneous melanoma (MC) is an extremely aggressive cancer with low survival and high
mortality. The vast majority of patients affected by this disease have metastasis and resistance
to chemotherapy, making ...
Estudo translacional do efeito protetor do guaraná (Paullinia cupana) na exposição ao metilmercúrio
(Universidade Federal de Santa Maria, 2018-08-14)
Mercury (Hg) is a known environmental pollutant, especially methylmercury (MeHg) that is toxic during
the development of the central nervous system, which can lead to neuromotor impairment, depression,
insomnia and ...
Efeitos da dieta contendo disseleneto de difenila sobre respostas comportamentais, bioquímicas e moleculares em um modelo de hiperglicemia em peixe-zebra
(Universidade Federal de Santa Maria, 2018-08-06)
Studies have been demonstrating an increasing number of secondary complications caused by diabetes. Among them are neuropsychiatric diseases such as anxiety and depression. In addition, oxidative stress is known to play a ...
Mecanismos de ação do resveratrol na diferenciação neural in vitro e na sinalização purinérgica em camundongos infectados com Toxoplasma gondii
(Universidade Federal de Santa Maria, 2018-09-24)
Central nervous system (CNS) development involves events that include the proliferation of neural precursor cells (NPCs) that differentiate and migrate in a process for creating connections and networks. In this context ...
Privação de sono em Drosophila melanogaster resulta em alterações na homeostase redox, mitocondrial e na expressão gênica de reguladores da função circadiana e metabólica
(Universidade Federal de Santa Maria, 2019-08-29)
Sleep deprivation and related diseases, such as metabolic disorders, are consequences of the
busy lifestyle of modern society. Sleep is a crucial resting state for survival and regulated by
circadian rhythms. Changes in ...