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Adição do óleo de Melaleuca alternifolia na dieta de peixes minimiza efeitos tóxicos causados pelo consumo diário de aflatoxina
(Universidade Federal de Santa Maria, 2020-04-09)
Mycotoxins are natural toxins produced through the secondary metabolism of toxigenic fungi. More than 400 classes of mycotoxins are found, however, as aflatoxins (AFs), produced mainly by Aspergillus species, including ...
Depressão e prejuízo de memória induzidos pela administração de estreptozotocina em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-20)
Pre-diabetes and diabetes are metabolic diseases of heterogeneous etiopathology including defects in
the secretion and action of insulin, or both, the presence of hyperglycemia, glucose and insulin
intolerance, disorders ...
JM-20 como composto multialvo: avaliação do potencial antioxidante, inibidor de colinesterases e citotoxicidade
(Universidade Federal de Santa Maria, 2020-10-29)
Multi-target compounds have aroused the interest of many researchers. The main characteristic of these substances is the ability to act through different mechanisms of action, a relevant fact in cases of pathologies caused ...
Neuroproteção do cassis (Ribes nigrum L.) e de sua associação com o Donepezil em modelo de amnésia induzida por escopolamina
(Universidade Federal de Santa Maria, 2019-12-13)
Memory deficits that occur with the process of aging could also be associated with the pathophysiology of neurodegenerative diseases, such as Alzheimer’s disease (AD). AD is characterized by the progressive deterioration ...
Disfunção imune em indivíduos HIV positivos sob terapia antirretroviral: papel da razão CD4/CD8 e da atividade da enzima adenosina desaminase
(Universidade Federal de Santa Maria, 2021-03-31)
Human immunodeficiency virus (HIV) uncontrolled replication results in the Acquired
Immunodeficiency Syndrome (AIDS). Antiretroviral therapy (ART) reduces morbidity
and mortality but inflammation and immune activation ...
Depressão induzida pela administração de dexametasona em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-19)
Different animal models already reported that the administration of DEX can induce phenotypic behaviors of depression and anxiety, as well as brain molecular changes. However, most studies report on the effects of DEX from ...
Agressividade e ansiedade induzidas pelo estresse em peixe-zebra: envolvimento da monoamina oxidase, modulação redox e alterações neuroendócrinas
(Universidade Federal de Santa Maria, 2020-07-24)
Mental disorders are considered XXI century pandemics that cause various health diseases. About a third of people have problems related to mental health worldwide. Furthermore, several disorders are triggered by exacerbated ...
Parâmetros moleculares e bioquímicos sobre a exposição per os aguda e crônica a xenobióticos eletrofílicos em insetos-modelos
(Universidade Federal de Santa Maria, 2020-08-13)
Continuous exposure to small doses of toxic substances elicit changes in the transcriptional profile and function of proteins before causing physical damage to organisms. Toxic effects can appear even after exposure stops. ...
Efeito toxicológico em ninfas de Nauphoeta cineria (Blattodea:Blaberidae) expostas por inalação ao 4-vinilciclohexeno
(Universidade Federal de Santa Maria, 2019-10-28)
Exposure to numerous toxic agents, including occupational exposure to volatile organic
compounds has generated numerous health problems in humans, which are correlated
to the emergence of numerous diseases. The volatile ...
Fibras musculares oxidativas e glicolíticas apresentam resposta inflamatória e alterações bioenergéticas peculiares após uma contusão musculoesquelética em ratos
(Universidade Federal de Santa Maria, 2021-02-19)
Muscle contusion represents a type of stress that disrupts cell homeostasis. Characterized by traumatic lesion, that impair the availability of oxygen (O2) in the tissue, promotes an increase in the production of reactive ...