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Ação neuroprotetora do composto ebselen e do exercício físico em modelos de doença de Alzheimer esporádica em camundongos
(Universidade Federal de Santa Maria, 2019-02-22)
Alzheimer's Disease (AD) is a neurodegenerative disease that reaches about 47 million people
in the world and this prevalence is expected to increase over the next two decades. A range of
evidence has shown that ...
Desbalanço superóxido-peróxido de hidrogênio versus seleno-L-metionina e castanha-do-Brasil: regulação diferencial in vitro de (seleno)enzimas
(Universidade Federal de Santa Maria, 2017-08-01)
Introduction: The coupled enzymatic reactions between the manganese-dependent superoxide dismutase (MnSOD/SOD2) and selenoenzyme glutathione peroxidase-1 (GPx-1) selenoenzyme are essential for mitochondrial redox balance ...
Efeito do suco de uva (vitis labrusca, bordô) sobre indicadores fisiopatológicos e bioquímicos da síndrome aguda da radiação em ratos wistar
(Universidade Federal de Santa Maria, 2010-03-03)
Exposure to radiation has toxic effects and for this reason research on food or drugs with positive radiomodifying action (protective) is of outmost interest to Public Health and Consumer Protection. Thus, the aim of this ...
Estudo da toxicidade induzida por metilglioxal em células sanguíneas humanas: efeito protetor do Syzigium cumini
(Universidade Federal de Santa Maria, 2017-09-01)
Methylglyoxal (MG) is a α-oxoaldehyde compound formed mainly as co-product from
glycolysis. Due its high glicative capacity, it is considered the major precursor of advanced
glycation end-products (AGEs). Although the ...
Benznidazol livre e nanoestruturado na terapia da Doença de Chagas experimental e seus efeitos sobre biomarcadores do sistema colinérgico e estresse oxidativo
(Universidade Federal de Santa Maria, 2022-01-27)
Chagas disease (CD) is widely distributed in Latin America, caused by Trypanosoma cruzi. The infection promotes an inflammatory process, which triggers several factors of the immune response. The cholinergic system acts ...
Efeito antitumoral da berberina em linhagem de células SK-MEL-28 de melanoma
(Universidade Federal de Santa Maria, 2022-01-10)
Melanoma is the most aggressive form of skin cancer, having high metastatic power, responsible for causing the majority (75%) of skin-related deaths. The metastatic power of tumor cells is a major challenge for therapeutic ...
Avaliação do potencial neuroprotetor da taurina em fenótipos comportamentais e neuroendócrinos associados à esquizofrenia em peixes-zebra
(Universidade Federal de Santa Maria, 2022-03-11)
Schizophrenia is a chronic neuropsychiatric disease that comprises a complex set of symptoms,
which represent a challenge for its study. One of the main experimental strategies for obtaining
phenotypes related to ...
Efeito neuroprotetor do JM-20 em ratos submetidos a traumatismo cranioencefálico leve
(Universidade Federal de Santa Maria, 2021-09-10)
Traumatic brain injury (TBI) is a multisystemic pathology with interactions between central nervous system, peripheral nervous system and immune system. It is one of the main causes of death and desability worldwide. The ...
Caracterização enzimática da e-ntpdase em linfócitos residentes de orgãos imunes primários, secundários e não imunes de ratos wistar
(Universidade Federal de Santa Maria, 2021-09-03)
Ectoenzymes play an important role in controlling the signaling developed by adenine nucleotides and nucleosides in countless cells. However, little information is found in the scientific literature about the biochemical ...
Mecanismos neurológicos e sistêmicos envolvidos na patogênese da listeriose e impactos do uso de curcumina livre e nanoencapsulada na infecção in vivo
(Universidade Federal de Santa Maria, 2021-10-27)
Foodborne zoonotic disease, listeriosis contains numerous gaps in knowledge regarding its pathogenic mechanisms. In addition, the problem of bacterial resistance requires potential alternatives to treatment. The aim of ...