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Efeito do tipo antidepressivo do 7-flúor-1,3-difenilisoquinolina-1-amina em modelos de estresse em roedores
(Universidade Federal de Santa Maria, 2018-03-23)
Current treatments for depression are inadequate for many patients and progress in understanding of this psychiatric disease is slow. The isoquinoline is an important class of molecules with antidepressant-like effect in ...
O sistema opioide contribui para o efeito do tipo antidepressivo do disseleneto de m-trifluormetil-difenila em camundongos
(Universidade Federal de Santa Maria, 2018-07-20)
Depression is a mental disorder with complex pathophysiology and characterized by multiple symptoms, which makes it difficult to treat this disease. In the last decades, the opioid system has become the focus of depression ...
Papel do sistema purinérgico no lúpus eritematoso sistêmico: um estudo clínico e de revisão
(Universidade Federal de Santa Maria, 2018-12-18)
Systemic Lupus Erythematosus (SLE) is a multifactorial inflammatory autoimmune disease caused by an immune dysfunction characterized by a breakdown of immune self-tolerance, activation of autoreactive T lymphocytes and B ...
Efeito de compostos naturais no envelhecimento e em modelos de doença de Alzheimer no nematódeo Caernorhabditis elegans
(Universidade Federal de Santa Maria, 2018-09-05)
During ageing, the cell repair system, including adaptative response to oxidative stress and unfolded protein degradation. In last decades, the increasing life expectancy, added to genetic and ambiental factors, has ...
Avaliação dos efeitos de calcogenonucleosídeos derivados da zidovudina usando células sanguíneas como alvo toxicológico
(Universidade Federal de Santa Maria, 2018-02-23)
Zidovudine (AZT), a thymidine derivative, is widely used in antiretroviral regimens and more recently it has been indicated, in combination with other chemotherapeutics, for the treatment of some types of cancer. Patients ...
Avaliação do potencial terapêutico do extrato aquoso de Peumus boldus (boldo) frente à toxicidade induzida por ferro e cobre em diferentes modelos experimentais
(Universidade Federal de Santa Maria, 2018-08-10)
The transition metals iron (Fe2+) and copper (Cu2+) are vital trace elements due to oxi-reducing
properties. However, the free Fe2+ and Cu2+ accumulation can lead to oxidative stress (OS), by catalisis
the Fenton reaction. ...
Camundongos infectados experimentalmente com Trypanosoma cruzi: efeito da doença de chagas sobre as enzimas purinérgicas e testes de um novo protocolo tripanocida
(Universidade Federal de Santa Maria, 2018-02-09)
Chagas disease is a zoonosis caused by Trypanosoma cruzi. It occurs primarily in Latin America, where it causes serious health problems for about 7 million people in endemic regions. Considering that Chagas disease currently ...
Envolvimento do estresse oxidativo e dos sistemas colinérgico e purinérgico na esclerose múltipla: estudo clínico e de revisão
(Universidade Federal de Santa Maria, 2018-02-23)
Multiple sclerosis (MS) is one of the main chronic inflammatory diseases of the central nervous system
(CNS) that cause functional disability in young adults. It is considered one complex autoimmune and
neurodegenerative ...
Estudo translacional do efeito protetor do guaraná (Paullinia cupana) na exposição ao metilmercúrio
(Universidade Federal de Santa Maria, 2018-08-14)
Mercury (Hg) is a known environmental pollutant, especially methylmercury (MeHg) that is toxic during
the development of the central nervous system, which can lead to neuromotor impairment, depression,
insomnia and ...
Efeitos da dieta contendo disseleneto de difenila sobre respostas comportamentais, bioquímicas e moleculares em um modelo de hiperglicemia em peixe-zebra
(Universidade Federal de Santa Maria, 2018-08-06)
Studies have been demonstrating an increasing number of secondary complications caused by diabetes. Among them are neuropsychiatric diseases such as anxiety and depression. In addition, oxidative stress is known to play a ...