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Estudo da ação antipsicótica e efeitos colaterais do haloperidol nanoencapsulado em ratos
(Universidade Federal de Santa Maria, 2012-06-29)
Haloperidol is a typical neuroleptic widely used in the treatment of several psychotic disorders and it remains the most prescribed antipsychotic worldwide, due to its high potency and low cost. Despite its good therapeutic ...
Avaliação do sistema purinérgico na pitiose experimental em coelhos tratados com imunoterápico
(Universidade Federal de Santa Maria, 2012-12-19)
Pythiosis is a disease caused by the oomycete Pythium insidiosum that affects
horses, cattle, sheep, cats and humans, and occurs in tropical, subtropical and
temperate regions. In horses the lesions are characterized by ...
Produtos apícolas como antioxidantes em peixes frente a desafios oxidantes provocados por tebuconazole
(Universidade Federal de Santa Maria, 2013-10-25)
This paper present alternatives to mitigate the deleterious effects caused by pesticides from
crops that contaminate ponds and water bodies, located very close to the growing areas. This
proximity causes oxidative damage ...
Papel do receptor TRPV1 em um modelo articular de gota aguda em ratos
(Universidade Federal de Santa Maria, 2014-02-17)
The gout is an extremely painful type of arthritis. Despite the large number of drugs available for its treatment, they usually cause many adverse effects that limit their use. Then, further investigations are necessary ...
Avaliação do eugenol e de óleos essenciais na redução do estresse em aquicultura
(Universidade Federal de Santa Maria, 2014-01-07)
This study evaluated the anesthetic efficacy of eugenol and essential oils (EOs) of Aloysia
triphylla and Lippia alba on aquaculture, as well as their stress-reducing effect during
transport of shrimp and fish. The ...
Influência de estrógenos e progestinas sobre a atividade da superóxido dismutase e o estatus oxidativo em mulheres
(Universidade Federal de Santa Maria, 2013-05-20)
The deficit of estrogen that accompanies menopause may be involved in the metabolic changes and increased oxidative stress during non-reproductive female life. Hormone replacement therapy (HRT) has been used to attenuate ...
O exercício físico reduz parâmetros comportamentais e moleculares envolvidos na drogadição por anfetamina em ratos: envolvimento da via opioide endógena
(Universidade Federal de Santa Maria, 2023-09-15)
The mesolimbic dopaminergic system constitutes a drug target circuit, whose neuroplasticity
alteration is involved in the development of drug addiction. Due to this neuromodulation,
currently available treatments only ...
Prescrição de fármacos inapropriados em idosos hospitalizados: análise da mortalidade e sobrevida
(Universidade Federal de Santa Maria, 2023-09-29)
Introduction: Elderly people (>60 years old) have a high prevalence of chronic noncommunicable diseases (DCNTs), often managed through the daily use of four or more
drugs (polypharmacy). Furthermore, they may present ...
Consequências da exposição ao levonorgestrel em zebrafish: efeitos persistentes e transgeracionais
(Universidade Federal de Santa Maria, 2023-09-18)
The consumption of contraceptive medications such as levonorgestrel (LNG) has
increased considerably in recent decades, and consequently its disposal in the
environment, and it has already been detected in different ...
Influência da dose de cetamina e da pioglitazona em sintomas tipo-esquizofrenia e marcadores bioquímicos em camundongos
(Universidade Federal de Santa Maria, 2023-10-31)
Schizophrenia is a severe mental illness characterized by positive, negative and cognitive symptoms, whose etiology is not fully elucidated, being cognitive symptoms difficult to treat. Ketamine is a non-competitive NMDA ...