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Efeitos neuroendócrinos e comportamentais do aripiprazol em zebrafish
(Universidade Federal de Santa Maria, 2019-01-17)
The aripiprazole (APPZ) is a second-generation atypical antipsychotic, which has been
increasingly used in the treatment of psychoses, such as schizophrenia, autism, bipolar
affective disorder, among others. The increasing ...
O efeito neuroprotetor da Espermina em condições de inflamação ocorre via BDNF, ativação do receptor TrkB, CREB e alteração na neurogênese
(Universidade Federal de Santa Maria, 2019-06-11)
Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and disrupting memory pathway and neurogenesis. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS ...
Citral como aditivo na dieta de peixes estuarinos: perfil redox, imunidade inata e parâmetros hepáticos
(Universidade Federal de Santa Maria, 2019-06-27)
Citral is a monoterpenoid that occurs in essential oils of different plant species used in folk medicine, which also showed promising effects when added to fish diets. However, in spite of the numerous biological activities ...
Influência da exposição ao modafinil sobre a preferência por anfetamina em diferentes períodos do desenvolvimento
(Universidade Federal de Santa Maria, 2019-11-22)
Addiction, which is characterized by the desire and the search for the drug, despite negative
consequences, is a serious health problem, causing impairments to the individual, your family, and
society. Thus, the developing ...
Investigação dos mecanismos associados ao efeito cicatrizante e regenerativo do barbatimão (Stryphnodendron adstringens) em modelos celulares in vitro
(Universidade Federal de Santa Maria, 2019-03-11)
Introduction: The skin is the largest organ of the human body and has the functions of coat, delimitate, protec and interact with the external environment. Skin lesions affect the general population, regardless of gender, ...
Aspectos comportamentais, bioquímicos e moleculares implicados no papel do magnésio nos distúrbios motores induzidos experimentalmente em ratos
(Universidade Federal de Santa Maria, 2019-02-08)
The chronic use of typical antipsychotics has been related to movement disorders development, which are manifested by repetitive, tremors and tardive dyskinesias, manifestations that can reach disabling levels and impair ...
Influência do polimorfismo genético Val16Ala-SOD2 e da matriz química do guaraná no estado oxidativo-inflamatório in vitro do cloridrato de ziprasidona
(Universidade Federal de Santa Maria, 2019-03-12)
Antipsychotics (APs) are used to treat schizophrenia and other psychiatric disorders. Most of these
medications have adverse effects causing obesity and metabolic changes associated with oxidative
stress ...
Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2019-06-03)
The dopaminergic system is the subject of numerous researches due to its complexity and to have numerous pathways and receptors in the central nervous system. The release of catecholamines such as dopamine and norepinephrine, ...
Influência de fatores farmacológicos e nutricionais na resposta oxidativa-inflamatória in vitro induzida pela olanzapina
(Universidade Federal de Santa Maria, 2019-03-13)
Introduction: Olanzapine (OLZ) is a second generation antipsychotic (ASG) used in the treatment of
schizophrenia, bipolar disorder and other neuropsychiatric conditions. The adverse effects of ASG
include ...
Nutrição e metabolismo ósseo
(Universidade Federal de Santa Maria, 2019-07-12)
Although intake of fruits and vegetables seemed to have a protective effect on bone metabolism, its effect on fractures remains uncertain. Some studies have described an impairment in quality of life of vitamin-deficient ...