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Desenvolvimento de formas farmacêuticas sólidas e semissólidas contendo piperina associada a nanocarreadores
(Universidade Federal de Santa Maria, 2018-08-17)
The possibility of associating natural actives with nanostructured systems appears as a less invasive
treatment option for the organism. This is because, nanoparticles are able to control the release and
attenuate the ...
Ruellia angustiflora (Nees) Lindau Ex Rambo (Acanthaceae): estudo químico e biológico
(Universidade Federal de Santa Maria, 2020-03-27)
Ruellia angustiflora (Nees) Lindau Ex Rambo (Acanthaceae) is popularly known as “fire flower” and its leaves are used to promote wound healing, but there is no scientific evidence to support its popular use. This thesis ...
Hesperozygis ringens (Benth). Epling: caracterização química e atividade biológica
(Universidade Federal de Santa Maria, 2020-03-26)
Hesperozygis ringens (Benth.) Epling (Lamiaceae), is an aromatic plant, endemic to southern
Brazil, it is popularly used as an insecticide, but it is not properly studied in the literature. In
view of this gap, the ...
Desenvolvimento e estudo da atividade antitumoral in vitro de nanopartículas poliméricas pH-sensíveis conjugadas com transferrina para liberação vetorizada de doxorrubicina
(Universidade Federal de Santa Maria, 2020-08-31)
Doxorubicin (DOX) is an anthracycline antibiotic widely used in cancer therapy, being
effective against a number of tumors. However, its use may promote the development of
multidrug resistance on tumor cells beside other ...
Aspergillus spp.: suscetibilidade aos antifúngicos isolados e em associação por diferentes metodologias e detecção de mecanismos de resistência a azólicos
(Universidade Federal de Santa Maria, 2018-01-19)
Aspergillosis is a group of diseases among the main causes of morbidity and mortality in immunosuppressed patients. Aspergillus fumigatus is the most common species that causes invasive and non-invasive aspergillosis in ...
Suscetibilidade in vitro e in vivo de Pythium insidiosum frente a antibacterianos (macrolídeos, oxazolidinonas e pleuromutilinas) e miltefosina
(Universidade Federal de Santa Maria, 2018-08-20)
Pythiosis is an infection caused by the oomycete Pythium insidiosum that affects humans and other wild and domestic mammals, presenting difficulties in both diagnosis and treatment. Pythiosis cases do not respond satisfactorily ...
Erva-mate (Ilex paraguariensis) e saúde: um estudo no metabolismo ósseo e sistema cardiovascular em mulheres pós-menopausa
(Universidade Federal de Santa Maria, 2018-07-05)
Menopause is an event characterized by the complete cessation of menstrual cycles as a
consequence of the important reduction of serum estrogen levels, which leads to increased
chronic diseases (osteoporosis, coronary ...
Desenvolvimento de micropartículas e comprimidos microparticulados contendo piperina
(Universidade Federal de Santa Maria, 2019-08-30)
Piperine is an alkaloid extracted from plants of the Piper genus, among which is the Piper nigrum species, the black pepper, widely employed in Indian cooking and traditional medicine. Moreover, piperine exhibits important ...
Efeito da dieta contendo rutina sobre a inflamação, apoptose e a resposta antioxidante em jundiás (Rhamdia quelen) infectados com Aeromonas hydrophila
(Universidade Federal de Santa Maria, 2019-05-30)
Fish culture conditions lead fish as silver catfish (Rhamdia quelen) to stressful situations, making them more susceptible to diseases caused by bacteria, including Aeromonas hydrophila. Thus, there is a real need to improve ...
Efeito protetor da N-acetilcisteína sobre o estresse oxidativo causado pela administração crônica de aspartame em ratos
(Universidade Federal de Santa Maria, 2015-03-12)
This thesis evaluated the N-acetylcysteine effects (150 mg/kg, intraperitoneal) on the
biochemical and oxidative changes caused by the daily oral consumption of aspartame at 40
mg/kg for six weeks by rats. For this ...