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Otimização de nanoemulsões contendo óleo essencial de tomilho: estabilidade, atividade antifúngica e liberação in vitro
(Universidade Federal de Santa Maria, 2019-07-02)
The main objective of this work was the optimization of nanoemulsions containing Thymus vulgaris essential oil (20 mg/mL) obtained from the high speed homogenization method, without the use of organic solvents and high ...
Determinação de benzodiazepínicos em plasma por cromatografia líquida com detector ultravioleta-visível empregando microextração líquido-líquido dispersiva
(Universidade Federal de Santa Maria, 2020-03-27)
Drugs has been the main agents involved in intoxications in Brazil. According to the latest
report of SINITOX, these agents summed up 20367 cases representing 26,79% of all agents
involved. Among them, 9983 cases were ...
Determinação de impurezas elementares em suplementos alimentares por espectrometria de absorção atômica
(Universidade Federal de Santa Maria, 2018-08-02)
This work presents a study of the determination of arsenic, cadmium and lead in food
supplements by atomic absorption spectrometry. Food supplements are obtained in synthetic
form and derived from plants, and contamination ...
Avaliação da atividade fotodinâmica frente a agentes de micoses cutâneas e subcutâneas
(Universidade Federal de Santa Maria, 2018-08-24)
Cutaneous and subcutaneous mycoses affect both immunocompeten individuals and immunocompromised individuals. Generally prolonged therapeutic treatments and, recurrences during treatment are quite common. Scopulariopsis ...
Avaliação de potência/teor de toxina botulínica tipo a por métodos cromatográficos e bioensaios
(Universidade Federal de Santa Maria, 2018-07-24)
The botulinum toxin type A is one of the seven different serotypes of toxins produced by fermentation process with Clostridium botulinum, under anaerobic conditions. Biotechnological product has been used in therapeutic ...
Molécula de dano renal-1 na urina e sua associação com o controle glicêmico e com a concentração urinária das interleucinas 1 e 6 no diabetes tipo 2
(Universidade Federal de Santa Maria, 2018-08-17)
Diabetes kidney disease (DRD) is among the main and most relevant complications of diabetes mellitus (DM). Hyperglycemia and inflammation are two of several factors involved in the development and progression of DM ...
Sistemas de base nanotecnológica contendo disseleneto de difenila para o tratamento do melanoma e do glioma
(Universidade Federal de Santa Maria, 2018-08-31)
Cancer is one of the diseases with the highest mortality in Brazil and worldwide. In addition, the conventional therapies present low efficacy and high toxicity. In this context, the diphenyl diselenide [(PhSe)2], an ...
Modelo PAMPA para estudo comparativo da permeabilidade de compostos fenólicos isolados e a partir de extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2018-08-29)
The use of natural compounds from the Brazilian national flora provides the population
access to treatment of various disorders and the development of new therapeutic
products. Therefore, it is important that permeation ...
Identificação de substâncias majoritárias presentes na Equisetum hyemale e avaliação das atividades antimicrobiana, antibiofilme, cito e genotóxicas
(Universidade Federal de Santa Maria, 2020-03-30)
Biofilms are clusters of microbial cells, adhered to a surface and protected by layers of extracellular polymeric substances (SPE). A large proportion of infections related to the use of implants and medical devices are ...
Desenvolvimento e avaliação biofarmacêutica de supositórios de doxiciclina hiclato para uso veterinário
(Universidade Federal de Santa Maria, 2018-08-17)
Veterinary drug therapy can be quite laborious especially when performed in the home environment. Usually the animal drug treatment is done by the oral or injectable route, but the rectal route can be an alternative. The ...