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Reposicionamento e avaliação da atividade antibacteriana e de clivagem do DNA plasmidial in vitro dos não antibióticos Anlodipino e Valsartana
(Universidade Federal de Santa Maria, 2019-12-19)
Infections caused by multiresistant microrganisms have increased considerably in recent years,
reaching approximately one fifth of worldwide mortality, becoming a public health problem. Another
worrying factor is the ...
Avaliação da Vanillosmopsis arborea Baker e (-)-α-bisabolol frente a parâmetros oxidativos e toxicológicos
(Universidade Federal de Santa Maria, 2017-08-18)
Vanillosmopsis arborea Baker belongs to the Asteraceae family and has a recognized economic value due to its anti-inflammatory properties, derived from sesquiterpene (-)-α-bisabolol (BISA), which is present in high ...
Atividade ovicida e larvicida de óleos essenciais em Sarconesia chlorogaster (Diptera: Calliphoridae)
(Universidade Federal de Santa Maria, 2016-02-19)
The parasitism by insects is a matter of great importance in tropical countries, where the climatic conditions favor their development. Among the parasites of importance we can highlight Diptera, such as flies, which because ...
Avaliação in vitro da atividade de antimicrobianos na cavidade bucal sobre Candida glabrata sensíveis e resistentes ao fluconazol
(Universidade Federal de Santa Maria, 2016-03-21)
Oropharyngeal candidiasis is a challenging fungal disease in the clinical setting of immunocompromised patients, either by their morbidity or by its difficulties in treatment. Patients with AIDS, cancer, and transplanted ...
Influência de fatores farmacológicos e nutricionais na resposta oxidativa-inflamatória in vitro induzida pela olanzapina
(Universidade Federal de Santa Maria, 2019-03-13)
Introduction: Olanzapine (OLZ) is a second generation antipsychotic (ASG) used in the treatment of
schizophrenia, bipolar disorder and other neuropsychiatric conditions. The adverse effects of ASG
include ...
Propriedades neurofarmacológicas da Euterpe oleracea: estudo in vitro do potencial uso no tratamento de doenças psiquiátricas
(Universidade Federal de Santa Maria, 2017-01-26)
Introduction: Neuropsychiatric diseases, as bipolar disorder (BD), have a very complex pathophysiology. Several times the diagnostic and to choose a correct treatment are difficult. Currently, have been developed studies ...
Desenvolvimento e validação de métodos cromatográficos para avaliação de teor/potência de insulina glargina
(Universidade Federal de Santa Maria, 2016-03-30)
hans, and is secreted into the bloodstream. It plays and important role in regulating the
metabolic activities of the body, particularly the homeostasis of the blood glucose. Insulin
glargine is a recombinant human insulin ...
Avaliação de potenciais biomarcadores séricos e salivares e do polimorfismo do gene da glutationa S-transferase P1 (GSTP1) na obesidade adulto jovem
(Universidade Federal de Santa Maria, 2015-11-20)
Obesity and overweight are complex clinical syndromes responsible for high morbidity and
mortality throughout the world, as they are risk factors for the development of Metabolic
Syndrome, diabetes mellitus, dyslipidemia, ...
Estudo de métodos cromatográficos e ensaio biológico para avaliação do anticorpo monoclonal denosumabe
(Universidade Federal de Santa Maria, 2017-07-27)
Denosumab (DmAb) is a fully human monoclonal antibody that inhibits osteoclast formation, function and survival, reducing bone turnover and resorption. Structurally, it is a fully human immunoglobulin G2, yielding a molecular ...
Avaliação de potência de interferon beta -1b por métodos cromatográficos validados e bioensaio
(Universidade Federal de Santa Maria, 2017-07-27)
Interferon is a cytokine with antiviral, antiproliferative and immunomodulatory properties that influences cell metabolism, growth and differentiation. The recombinant human interferon β 1b (rhIFNβ-1b) is a non-glycosylated ...