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Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Discinesia espontânea em ratos: possível participação de mecanismos oxidativos e dopaminérgicos
(Universidade Federal de Santa Maria, 2017-08-17)
Tardive dyskinesia is a movement disorder that develops as a result of prolonged use of antipsychotics, mainly the typical ones, in approximately 20% to 25% of patients and, as age increases, it afflicts about 50% of ...
Citral como aditivo na dieta de peixes estuarinos: perfil redox, imunidade inata e parâmetros hepáticos
(Universidade Federal de Santa Maria, 2019-06-27)
Citral is a monoterpenoid that occurs in essential oils of different plant species used in folk medicine, which also showed promising effects when added to fish diets. However, in spite of the numerous biological activities ...
Polimorfismo Ala16ValMnSOD na epilepsia: envolvimento dos marcadores inflamatórios, oxidativos e glicolipídicos
(Universidade Federal de Santa Maria, 2019-08-17)
Epilepsy is a neurological disease that affects around 1% of world population, with neurobiological, neurochemical, cognitive and psychological consequences. Despite of the good prognosis, there is a high proportion of ...
O papel do polimorfismo Ala16Val da Mn-SOD no acidente vascular encefálico crônico: um estudo clínico
(Universidade Federal de Santa Maria, 2019-08-17)
Considered one of the most common neurological diseases, stroke has a high morbidity and mortality, and corresponds to 85% of disease cases. Several factors are involved in disease etiology, such as changes in vascular ...
Efeitos do inseticida permetrina sobre o desenvolvimento de peixes-zebra
(Universidade Federal de Santa Maria, 2019-08-30)
Permethrin (PM) is a Type I synthetic pyrethroid (SP) widely used in crops and especially in domestic environments to control harmful insects. Pyrethroids are considered safe, with low mammalian toxicity. However, studies ...
Ação protetora da Carya illinoensis sobre a toxicidade induzida por ciclofosfamida em ratos
(Universidade Federal de Santa Maria, 2010-01-29)
Cyclophosphamide (CP) is an alkylating agent widely used in anticancer and immunosuppression therapy. Like other chemotherapies, this drug can induce damage in healthy tissues, generating multiple organ toxicity. The study ...
Adição do óleo essencial de Lippia alba (Mill) N. E. Brown na dieta do jundiá: análise do crescimento e da resposta antioxidante
(Universidade Federal de Santa Maria, 2013-02-06)
Fish become more susceptible to stress and, consequently, to the onset of disease with the intensification of rearing. In an attempt to minimize this problem, farmers use agrochemicals that, besides harming the environment, ...
Avaliação do potencial terapêutico do extrato aquoso de Peumus boldus (boldo) frente à toxicidade induzida por ferro e cobre em diferentes modelos experimentais
(Universidade Federal de Santa Maria, 2018-08-10)
The transition metals iron (Fe2+) and copper (Cu2+) are vital trace elements due to oxi-reducing
properties. However, the free Fe2+ and Cu2+ accumulation can lead to oxidative stress (OS), by catalisis
the Fenton reaction. ...
Efeitos do consumo de sacarose sobre parâmetros metabólicos, desenvolvimentais e antioxidantes em Drosophila melanogaster: papel das plantas Syzygium cumini e Bauhinia forficata
(Universidade Federal de Santa Maria, 2014-03-14)
The fruit fly, Drosophila melanogaster, has been considered a suitable model organism for investigation of developmental/metabolic dysfunctions and therapeutic strategies. In this work Drosophila melanogaster larvae were ...