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Epidemiologia e investigação de mecanismos de resistência aos carbapenêmicos e polimixinas em bacilos gram-negativos multirresistentes
(Universidade Federal de Santa Maria, 2018-09-28)
Bacterial resistance is a global public health problem and leads to relapsing nosocomial infections, high morbidity and mortality rates and high financial impact. Carbapenems and polymyxins are extensively antimicrobials ...
Consequências da modulação farmacológica da Na+, K+ - ATPase na epilepsia induzida por pilocarpina
(Universidade Federal de Santa Maria, 2018-08-24)
Epilepsy is one of the most common chronic neurological diseases worldwide, and despite a variety of drugs introduced into clinical practice, one-third of patients remain unresponsive to therapies. In addition, when ...
Caracterização química e avaliação das atividades antimicrobiana, antinociceptiva e anti-inflamatória do própolis da Melipona quadrifasciata quadrifasciata
(Universidade Federal de Santa Maria, 2018-05-10)
The demand for natural products with biological application has become of great interest of
the scientific community and is not different from the products produced by the bees: honey,
propolis, wax and pollen. Several ...
Nanotecnologia potencializa a ação tripanocida do nerolidol em camundongos infectados com Trypanosoma evansi: envolvimento da barreira hematoencefálica
(Universidade Federal de Santa Maria, 2018-11-19)
In spite of significant advances in the studies against Trypanosoma evansi, the effective elimination of protozoan from the central nervous system (CNS) remains a difficult task. The incapacity of trypanocidal drugs ...
Efeitos de inibidores da enzima COX-2 sobre o desenvolvimento de crises convulsivas em camundongos
(Universidade Federal de Santa Maria, 2018-01-12)
Cyclooxygenase-2 (COX-2) inhibitors reduce the synthesis of prostaglandins (PGs) and play an important role in inflammation. In the last decades, research has been focused on the use of COX-2 inhibitors and the inflammatory ...
Interação entre o brometo de piridostigmina e o desbalanço superóxido-peróxido de hidrogênio na cito-genotoxicidade de células neurais e imunes mononucleares
(Universidade Federal de Santa Maria, 2018-06-11)
Pyridostigmine bromide (PB) is a reversible acetylcholinesterase inhibitor (AChE), and the first line of
symptoms associated with neuromuscular junction disorders (JNM) and has been used prophylactically
in the Persian ...
Suscetibilidade in vitro a antifúngicos, frações de óleos essenciais e modelo experimental de infecção por Malassezia pachydermatis
(Universidade Federal de Santa Maria, 2018-07-19)
Malassezia pachydermatis is a zoophilic yeast mainly found in the auditory canal of various animal species, and may also be isolated from the skin of humans. Azole and polyene antifungals are the treatment of choice for ...
Suscetibilidade in vitro de Conidiobolus lamprauges frente a fármacos antimicrobianos
(Universidade Federal de Santa Maria, 2018-08-23)
Conidiobolomycosis is an important and difficult-to-treat infection. The disease is caused by the fungi Conidiobolus coronatus, C. incongruus and C. lamprauges, affecting sheep, horses, dogs and humans. There is no common ...
Efeito do Stryphnodendron adstringens (Mart.) Coville em marcadores inflamatórios e proliferativos da cicatrização de feridas: um modelo bi-celular in vitro
(Universidade Federal de Santa Maria, 2018-07-19)
The skin is the largest organ in the human body and acts as a barrier protecting the body from the environment. The rupture of its integrity caused by an injury culminates in the activation of a complex healing process, ...
Potencial antibacteriano de fitoquímicos isolados ou em combinação com antimicrobianos frente à bactérias patogênicas para peixes
(Universidade Federal de Santa Maria, 2018-07-11)
Brazilian aquaculture production is intensifying, leading to an increase of bacterioses, causing economic losses in fish farms. This increases the use of antimicrobials, often indiscriminately, causing bacterial resistance ...