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Efeitos de compostos orgânicos de selênio na toxicidade induzida por metilmercúrio: estudos in vitro
(Universidade Federal de Santa Maria, 2014-10-23)
Methylmercury (MeHg) is a known environmental pollutant that affects a variety of cellular functions, and the
oxidative stress is one of the proposed mechanisms to explain its toxicity. Inhibition of selenoenzymes
(Glutathione ...
Avaliação de biomarcadores associados à inflamação e ao estresse oxidativo em pacientes com câncer de próstata
(Universidade Federal de Santa Maria, 2013-01-28)
Changes in recent decades in morbidity and mortality of prostate cancer (CAP) is
making if a public health problem in several countries, including Brazil. Several studies
provide evidence that inflammatory processes and ...
Caracterização físico-química do mel do bioma pampa brasileiro e estudo do seu potencial antioxidante in vitro e in vivo em modelo de Drosophila melanogaster
(Universidade Federal de Santa Maria, 2014-03-14)
Honey is a complex mixture produced by honey bees from the nectar, which is used by
its sweetening properties, as well as by its human health benefits. The aim of this study was to
characterize, for the first time in ...
Avaliação do estresse oxidativo e da atividade da enzima d-aminolevulinato desidratase em pacientes transplantados de medula óssea
(Universidade Federal de Santa Maria, 2008-12-19)
Bone marrow transplantation (BMT) has been used in the treatment of a number of
diseases. Before BMT, patients are submitted to a conditioning regime (CR) that consists of
administration of high doses of chemo- or ...
Avaliação do fibrinogênio como uma nova fonte para a formação in vitro de produtos proteicos de oxidação avançada
(Universidade Federal de Santa Maria, 2015-07-08)
Oxidative stress is characterized by an imbalance between the production of free radicals, particularly reactive oxygen species (ROS), and the defense capacity of the organism against these species, leading to a progressive ...
Atividade hipolipidêmica do disseleneto de difenila na hiperlipidemia induzida por Triton WR-1339 em camundongos
(Universidade Federal de Santa Maria, 2009-11-26)
In mammals, the liver plays a central role in whole-body lipid metabolism. Unfortunately, dysregulation of these pathways has been implicated in hyperlipidemias. In recent years, a significant association between the trace ...
Atividade da delta aminolevulinato desidratase sangüínea e o estresse oxidativo em pacientes hemodialisados
(Universidade Federal de Santa Maria, 2007-03-09)
The acid aminolevulinato dehydratase (δ-ALA-D) is a thiol enzyme involved in tetrapirrólicos composite biosynthesis, as heme. This enzyme is inhibited by some metals, having been also its inhibition a pointer of poisoning ...
Ação neuroprotetora do composto ebselen e do exercício físico em modelos de doença de Alzheimer esporádica em camundongos
(Universidade Federal de Santa Maria, 2019-02-22)
Alzheimer's Disease (AD) is a neurodegenerative disease that reaches about 47 million people
in the world and this prevalence is expected to increase over the next two decades. A range of
evidence has shown that ...
Vitamina C plasmática está negativamente associada com a atividade das aminotransferases em pacientes com hepatite C não tratados
(Universidade Federal de Santa Maria, 2007-04-20)
In this study, the possible relationship between aminotransferase activities and markers of oxidative stress in hepatitis C patients was evaluated. Patients with HCV
(hepatitis C virus) infection confirmed by positive HCV ...
Cisplatina induz um padrão de toxicidade hepatorrenal diferente em ratos neonatos e adultos
(Universidade Federal de Santa Maria, 2018-07-20)
Cisplatin is a widely used chemotherapeutic to treat several types of tumors on both adult and pediatric subjects. Although cisplatin is widely used, its use is associated with serious toxic effects, including nephrotoxicity ...