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Validação de bioensaio por cultura de células para avaliação de potência de rhEPO e correlação com bioensaio in vivo e métodos cromatográficos
(Universidade Federal de Santa Maria, 2014-08-12)
Erythropoietin is a hematopoietic hormone and the main physiological function is the induction of erythropoiesis. Recombinant DNA technology enabled cloning and expression of rhEPO gene to produce recombinant human ...
Avaliação dos níveis de albumina modificada pela isquemia, um novo biomarcador de estresse oxidativo, em pacientes com artrite reumatoide
(Universidade Federal de Santa Maria, 2013-01-15)
Rheumatoid arthritis (RA) is a chronic inflammatory, autoimmune disease, characterized by peripheral and symmetrical polyarthritis that leads to joint destruction and deformity due to erosion of cartilage and bone. This ...
Secagem por aspersão de nanocápsulas de núcleo lipídico contendo tretinoína: desenvolvimento e incorporação em hidrogéis
(Universidade Federal de Santa Maria, 2010-12-07)
The aim of this work was to study the ability of lipid-core polymeric nanocapsules to protect tretinoin against UV degradation, even after their conversion to spray-dried powders and also to evaluate the feasibility of ...
Avaliação da atividade biológica in vitro da amitriptilina
(Universidade Federal de Santa Maria, 2019-08-29)
Theemergenceofinfectionscaused bymulti-drug resistantbacteriaworldwideand thesubstantialincreasein cancerhasled tothesearchforinnovativetherapies.Inthisway,theuseofresearcheswithdrugsalreadyinclinicalusethatcould ...
Atividade antimicrobiana de extratos de Maclura tinctoria (L) D. Don ex Steud contra patógenos de peixes
(Universidade Federal de Santa Maria, 2018-07-27)
The sanitary conditions to which the animals are submitted in aquaculture are often
inadequate, being stressing factors triggering pathological processes as bacterial infections. In
this context, bacterial ...
Frequência da mutação JAK2V617F em pacientes com trombocitose no interior do RS
(Universidade Federal de Santa Maria, 2020-03-06)
Myeloproliferative neoplasms (MPN) are unique hematopoietic stem-cell disorders, resulting in an
increased proliferation of single or multilineage mature hematopoietic cells. JAK2V617F mutation is a
diagnostic ...
Avaliação das toxicidades aguda e subaguda da Olea europaea L. e seu efeito no metabolismo de ratos diabéticos
(Universidade Federal de Santa Maria, 2016-03-04)
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insulin resistance and dyslipidemia. It is widely distributed worldwide, affecting millions of people and can lead to serious complications. ...
Desenvolvimento de métodos analíticos para determinação de impurezas em produtos farmacêuticos
(Universidade Federal de Santa Maria, 2019-03-12)
The presence of impurities in medicinal products is usually associated with their presence in the raw material and/or the production process of the drug itself. The presence of these impurities raises concern, not only ...
Avaliação das metodologias de detecção bacteriana e de resistência dos Staphylococcus coagulase negativa isolados das bolsas de concentrados plaquetários
(Universidade Federal de Santa Maria, 2015-05-22)
Platelet transfusion therapy has played an important role in the treatment of patients with hematological and oncological diseases. However, platelet transfusion represents a risk for bacterial sepsis. Platelet Concentrates ...
Investigação da resistência bacteriana e avaliação de metodologias em isolados clínicos de Pseudomonas aeruginosa e Acinetobacter spp. de diferentes anos em um hospital universitário
(Universidade Federal de Santa Maria, 2017-04-28)
Pseudomonas aeruginosa and Acinetobacter spp. are microorganisms worldwide reported as pathogens of high prevalence in the etiology of nosocomial infections; they are opportunistic and have clinical importance in Health ...