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Desenvolvimento de nanocarreadores a base de piperina: influência do polímero e citotoxicidade in vitro – in vivo
(Universidade Federal de Santa Maria, 2016-12-16)
This study aimed the development of nanoemultions and polymeric nanocapsule suspensions containing
piperine, in order to study their considering photodegradation and citotoxicity. To quantify piperine at the
nanostructures, ...
Avaliação fitoquímica, antioxidante e anti-inflamatória de Solanum corymbiflorum
(Universidade Federal de Santa Maria, 2017-02-20)
The plants have compounds that are related to different biological activities. Among these
compounds, stand out the phenolic compounds which are capable of eliminate free radicals,
and therefore, are involved in several ...
Efeitos de inibidores da enzima COX-2 sobre o desenvolvimento de crises convulsivas em camundongos
(Universidade Federal de Santa Maria, 2018-01-12)
Cyclooxygenase-2 (COX-2) inhibitors reduce the synthesis of prostaglandins (PGs) and play an important role in inflammation. In the last decades, research has been focused on the use of COX-2 inhibitors and the inflammatory ...
Influência de Harpagophytum procumbens sobre parâmetros comportamentais e moleculares em um modelo de discinesia orofacial em ratos
(Universidade Federal de Santa Maria, 2017-02-18)
Fluphenazine is a typical antipsychotic used for the treatment of schizophrenia. However, its chronic use has been related to the appearance of extrapyramidal side effects, such as tardive dyskinesia (TD). Studies suggest ...
Potencial antidepressivo do extrato aquoso de Ilex paraguariensis em roedores: envolvimento do sistema monoaminérgico
(Universidade Federal de Santa Maria, 2017-03-31)
Ilex paraguariensis is a plant largely consumed in South America as an infusion known as ―chimarrão‖ or ―mate‖, which shows effects related to its action in the central nervous system. However, little is known about its ...
Influência do consumo de gordura interesterificada sobre parâmetros comportamentais bioquímicos e moleculares em ratos
(Universidade Federal de Santa Maria, 2017-07-21)
Fatty acids are important constituents of neural phospholipid membranes where play an essential role in the central nervous system (CNS), modifying the plasticity and fluidity of these membranes, particularly during early ...
Alterações comportamentais, bioquímicas e moleculares em camundongos C57BL/6 machos após recuperação de malária cerebral
(Universidade Federal de Santa Maria, 2017-07-07)
Malaria, a parasitic disease, can be caused by different species of Plasmodium protozoan and it is transmitted by the bite of female Anopheles mosquitoes. Plasmodium falciparum is responsible for the most severe complication ...
Atividade antimicrobiana, antibiofilme, cito e genotóxica do S- (3,4-diclorobenzil) isotioureia (A22)
(Universidade Federal de Santa Maria, 2017-08-25)
Biofilm formation causes great public health concern due to the low response to antimicrobial
treatments and the colonization of surfaces such as prostheses and catheters. Pathogenic
microorganisms such as Pseudomonas ...
Gabapentina previne alterações comportamentais induzidas por anfetamina ou haloperidol em camundongos
(Universidade Federal de Santa Maria, 2017-12-19)
Schizophrenia is a chronic and highly complex psychiatric illness that manifests with a wide spectrum of changes that include cognitive, negative and positive symptoms. The drugs available for the treatment (antagonists ...
Interação entre o brometo de piridostigmina e o desbalanço superóxido-peróxido de hidrogênio na cito-genotoxicidade de células neurais e imunes mononucleares
(Universidade Federal de Santa Maria, 2018-06-11)
Pyridostigmine bromide (PB) is a reversible acetylcholinesterase inhibitor (AChE), and the first line of
symptoms associated with neuromuscular junction disorders (JNM) and has been used prophylactically
in the Persian ...