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Epidemiologia e investigação de mecanismos de resistência aos carbapenêmicos e polimixinas em bacilos gram-negativos multirresistentes
(Universidade Federal de Santa Maria, 2018-09-28)
Bacterial resistance is a global public health problem and leads to relapsing nosocomial infections, high morbidity and mortality rates and high financial impact. Carbapenems and polymyxins are extensively antimicrobials ...
Efeitos neuroendócrinos e comportamentais do aripiprazol em zebrafish
(Universidade Federal de Santa Maria, 2019-01-17)
The aripiprazole (APPZ) is a second-generation atypical antipsychotic, which has been
increasingly used in the treatment of psychoses, such as schizophrenia, autism, bipolar
affective disorder, among others. The increasing ...
Consequências da modulação farmacológica da Na+, K+ - ATPase na epilepsia induzida por pilocarpina
(Universidade Federal de Santa Maria, 2018-08-24)
Epilepsy is one of the most common chronic neurological diseases worldwide, and despite a variety of drugs introduced into clinical practice, one-third of patients remain unresponsive to therapies. In addition, when ...
Caracterização química e avaliação das atividades antimicrobiana, antinociceptiva e anti-inflamatória do própolis da Melipona quadrifasciata quadrifasciata
(Universidade Federal de Santa Maria, 2018-05-10)
The demand for natural products with biological application has become of great interest of
the scientific community and is not different from the products produced by the bees: honey,
propolis, wax and pollen. Several ...
Nanotecnologia potencializa a ação tripanocida do nerolidol em camundongos infectados com Trypanosoma evansi: envolvimento da barreira hematoencefálica
(Universidade Federal de Santa Maria, 2018-11-19)
In spite of significant advances in the studies against Trypanosoma evansi, the effective elimination of protozoan from the central nervous system (CNS) remains a difficult task. The incapacity of trypanocidal drugs ...
Aumento da suscetibilidade ao pentilenotetrazol após a sobrevivência de um quadro de malária cerebral em camundongos
(Universidade Federal de Santa Maria, 2017-07-10)
Malaria is considered a neglected disease and public health problem, affecting more than 200 million people worldwide. Plasmodium falciparum, one of the four human parasitic species, is responsible for the development of ...
O papel da amônia sobre as alterações comportamentais, neuroinflamação e apoptose em um modelo experimental de acidemia metilmalônica.
(Universidade Federal de Santa Maria, 2017-08-29)
Methylmalonic acidemia is an autosomal recessive metabolism biochemically characterized by
a deficiency in the activity of the mutase methylmalonyl-CoA and the tissue accumulation of
methylmalonate (MMA). In this acidemia, ...
Associação da via inflamatória e apoptótica na patofisiologia do acidente vascular encefálico tardio: relação com a dislipidemia
(Universidade Federal de Santa Maria, 2015-01-22)
Stroke occurs when blood flow to the brain is interrupted by an embolic or thrombotic occlusion of a cerebral artery (ischemic stroke) or by bleeding from a ruptured blood vessel (hemorrhagic stroke). Oxidative stress and ...
Efeito farmacogenético do polimorfismo Ala16Val do gene da MnSOD na resposta de pacientes hipercolesterolêmicos a rosuvastatina
(Universidade Federal de Santa Maria, 2015-02-27)
Rosuvastatin is used as a drug of first choice in treating hypercholesterolemia due to
competitive inhibition of HMG-CoA reductase enzyme which converts HMG-CoA to
mevalonic acid which is the rate-limiting step in ...
Caracterização molecular de enterobactérias resistentes aos carbapenêmicos
(Universidade Federal de Santa Maria, 2014-04-30)
Enterobacteriaceae resistant to carbapenems cause great impact on public health due to their different evolutionary mechanisms of resistance. The mechanism of resistance that recently has been reported in Enterobacteriaceae ...