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Avaliação da sinalização purinérgica em pacientes com Mieloma Múltiplo
(Universidade Federal de Santa Maria, 2016-08-25)
Multiple myeloma (MM) is an incurable hematological disorder characterized by clonal population of bone marrow plasma cells proliferation, which secrete monoclonal antibodies or fragments thereof, causing failure in normal ...
Mecanismos bioquímicos e moleculares envolvidos em efeitos comportamentais induzidos por reserpina em ratos e C. elegans com ênfase em parâmetros oxidativos e dopaminérgicos
(Universidade Federal de Santa Maria, 2015-01-16)
Animal models as reserpine are helpful to understand the pathophysiology of several diseases with involuntary movements, as Parkinson s disease (PD), and to search efficient treatments. The present study tested the effects ...
Avaliação das atividades citotóxica e antibacteriana de compostos triazenos
(Universidade Federal de Santa Maria, 2013-12-13)
Neoplasms are a major cause of death worldwide and have been worrying about the medical and scientific community, as most anticancer vector does not act on cancer cells, triggering numerous side-effects and, in some cases, ...
Efeito da anandamida nos movimentos de mascar no vazio induzidos por haloperidol em ratos: participação do receptor CB1
(Universidade Federal de Santa Maria, 2012-09-05)
Treatment with antipsychotic drugs may cause tardive dyskinesia in humans and orofacial dyskinesia in rodents. Although the dopaminergic system in basal ganglia has been implicated in these movement disorders, their ...
Efeitos de resíduos de psicofármacos na água sobre o desenvolvimento inicial de zebrafish
(Universidade Federal de Santa Maria, 2015-07-01)
The growing and continuous use of drugs by the human population transformed the
pharmacological agents in "emerging pollutants" are often found in aquatic
environments. The consequences of this finding are still unclear, ...
Efeitos do organofosforado parationato metílico sobre o eixo hipotálamo-hipófise-interrenal em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2013-04-18)
Organophosphorus compounds such as methyl-parathion are used in the various stages of production to control pests both in agricultural activity as in aquaculture. The mechanism of action of this type of compound is the ...
Efeito do extrato de Syzygium cumini e alterações provocadas pela síndrome metabólica sobre parâmetros bioquímicos e inflamatórios
(Universidade Federal de Santa Maria, 2013-12-04)
Metabolic syndrome (MetS) is a complex disorder represented by a set of cardiovascular risk factors, including endothelial dysfunction, oxidative stress and inflammation. Syzygium cumini has hypoglycemic, anti-inflammatory, ...
Efeitos do AMPc intracelular sobre a diferenciação de células progenitoras neurais
(Universidade Federal de Santa Maria, 2022-02-25)
Intermediate and extrinsic intrinsic stimuli contribute to the growth of progenitor cells (NPCs).
Extracellular stimuli cause NPCs to differentiate into glial cells and neurons. At the intracellular
level, as signaling ...
Comparação de metodologias para detecção da resistência à meticilina em Staphylococcus aureus
(Universidade Federal de Santa Maria, 2013-11-29)
Staphylococcus aureus is considered as a microorganism belonging to the normal flora of humans, being both a settler as an infectious pathogen Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a major cause ...
Papel da Na+, K+ - ATPase no modelo de epilepsia do lobo temporal em camundongos
(Universidade Federal de Santa Maria, 2015-03-16)
Epilepsy is a disease that affects about 1-2% of the general population. Considering the high number of patients with epilepsy who are refractory to currently available drugs, it is important to search for new anticonvulsant ...