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Itens para a visualização no momento 41-50 of 196
Efeitos da combinação de paracetamol e cafeína sobre a bioenergética mitocondrial em fígado de camundongos
(Universidade Federal de Santa Maria, 2017-07-28)
Paracetamol (acetaminophen, N-acetyl-p-aminofenol, APAP) is a drug with analgesic and antipiretic effects, widely used, presenting low cost, easier aquisition and clinical efficacy. Accidental or intentional use of high ...
Efeito do ácido cafeico e ácido cafeico fenetil éster em modelo de inflamação induzida por lipopolisacarídeo
(Universidade Federal de Santa Maria, 2016-08-05)
Peripheral inflammation is able to cause alterations in central nervous system (CNS) and lead to progression of neurodegenerative diseases. During neuroinflammatory process the activation of immune cells from the CNS and ...
Caenorhabditis elegans como modelo experimental para estudos toxicológicos e farmacológicos dos extratos de Luehea divaricata e Paullinia cupana
(Universidade Federal de Santa Maria, 2016-03-16)
The nematode Caenorhabditis elegans is a valuable tool for toxicological and
pharmacological studies. Despite its simple body, the most part of its genes and signaling
pathways are similar to humans, and alterations in ...
Envolvimento dos sistemas purinérgico, colinérgico e estresse oxidativo nos distúrbios da tireoide: possível efeito protetor da quercetina
(Universidade Federal de Santa Maria, 2017-02-22)
Thyroid hormones modulate the metabolic pathways in the body and have important physiological
functions in the brain and vascular system. Changes in their production or distribution lead to disorders
such as hypothyroidism ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Discinesia espontânea em ratos: possível participação de mecanismos oxidativos e dopaminérgicos
(Universidade Federal de Santa Maria, 2017-08-17)
Tardive dyskinesia is a movement disorder that develops as a result of prolonged use of antipsychotics, mainly the typical ones, in approximately 20% to 25% of patients and, as age increases, it afflicts about 50% of ...
Citral como aditivo na dieta de peixes estuarinos: perfil redox, imunidade inata e parâmetros hepáticos
(Universidade Federal de Santa Maria, 2019-06-27)
Citral is a monoterpenoid that occurs in essential oils of different plant species used in folk medicine, which also showed promising effects when added to fish diets. However, in spite of the numerous biological activities ...
Polimorfismo Ala16ValMnSOD na epilepsia: envolvimento dos marcadores inflamatórios, oxidativos e glicolipídicos
(Universidade Federal de Santa Maria, 2019-08-17)
Epilepsy is a neurological disease that affects around 1% of world population, with neurobiological, neurochemical, cognitive and psychological consequences. Despite of the good prognosis, there is a high proportion of ...
O papel do polimorfismo Ala16Val da Mn-SOD no acidente vascular encefálico crônico: um estudo clínico
(Universidade Federal de Santa Maria, 2019-08-17)
Considered one of the most common neurological diseases, stroke has a high morbidity and mortality, and corresponds to 85% of disease cases. Several factors are involved in disease etiology, such as changes in vascular ...
Análise do traumatismo cranioencefálico leve sobre a susceptibilidade a pentilenotetrazol e o efeito do pré-tratamento com cafeína em ratos
(Universidade Federal de Santa Maria, 2017-09-19)
Traumatic Brain Injury (TBI) is a public health problem, with a high incidence, debilitation and fatality in modern society, often resulting in neurological dysfunctions. These abnormalities after TBI have been shown to ...