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Mecanismos de toxicidade de Duguetia furfuraceae A. St.-Hill no modelo de Drosophila melanogaster e avaliação do potencial antifúngico.
(Universidade Federal de Santa Maria, 2015-12-04)
Duguetia furfuracea is a common shrub from Brazilian cerrado areas, known as "ata brava", often used as a medicinal plant especially in treatment of renal colic and rheumatism. However, pharmacological studies with extracts ...
Quantificação de α-tocoferol, retinol e carotenóides e seus possíveis efeitos sobre a peroxidação lipídica em trabalhadores expostos a solventes
(Universidade Federal de Santa Maria, 2011-02-18)
Oxidative stress is a process characterized by the antioxidant defense system
decrease and/or an excessive reactive species (RS) production. RS are substances
capable of attacking proteins, lipids and DNA. The oxidative ...
Respostas bioquímicas em carpas (Cyprinus carpio) expostas a duas formulações comerciais de inseticidas em condições de lavoura de arroz e em laboratório
(Universidade Federal de Santa Maria, 2012-07-27)
The pesticides are substances widely used in agriculture, because it enhances productivity. However, its excessive and disordered use has caused different impacts on the environment. Therefore, this study investigated the ...
Atividade antitumoral da berberina em células de neuroblastoma SH-SY5Y
(Universidade Federal de Santa Maria, 2017-02-23)
Neuroblastoma is the most common tumor found in the first year of life and represent 6% of the all childhood cancers. There is few options of treatment and the mortality is close to 21%, or exceeds 50% between the high ...
Efeito neuroprotetor da Berberina na neurotoxicidade induzida por estreptozotocina e lipolissacarídeo em ratos
(Universidade Federal de Santa Maria, 2019-10-29)
Alzheimer's disease (AD) is considered the major cause of dementia and is characterized by changes in the cholinergic and purinergic system, oxidative stress, inflammatory process and metabolic changes that, in turn, are ...
Interação entre silício e alumínio em genótipos de batata (Solanum tuberosum L.).
(Universidade Federal de Santa Maria, 2015-03-06)
Silicon (Si) and aluminum (Al) are among the three most abundant elements in the earth's crust. The Si does not meet the requirements of an essential element for plant growth, but the beneficial effects of this element in ...
Influência farmacogenética da enzima SOD2 na resposta in vitro ao resveratrol de células mononucleares
(Universidade Federal de Santa Maria, 2014-10-03)
Resveratrol (RES) is an anti-aging molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this ...
Influência do polimorfismo Ala16Val do gene da enzima superóxido dismutase (SOD2) no efeito antioxidante in vitro do citrato de clomifeno
(Universidade Federal de Santa Maria, 2011-08-16)
To investigate the in vitro antioxidant properties of the ovulation induction drug,
Citrate clomiphene (CC), and to access whether its effects are influenced by the
Ala16Val polymorphism in the SOD2 gene, which encodes ...
Associação do disseleneto de difenila e moduladores do sistema glutamatérgico frente ao dano oxidativo causado por ácido quinolínico
(Universidade Federal de Santa Maria, 2013-02-22)
Excessive formation of reactive oxygen species (ROS) and disruption of glutamate
uptake have been hypothesized as key mechanisms contributing to quinolinic acid (QA)-
induced toxicity. Thus, here we investigate if the ...
Silimarina modifica a atividade da Na+/K+-ATPase e da MAO e modula a ação de antimicrobianos in vitro
(Universidade Federal de Santa Maria, 2015-06-10)
The Silymarin is a flavonolignan complex isolated from milk thistle seeds of Silybum marianum being used in the treatment of injury related to oxidative stress, including liver and neurological diseases, as Parkinson ...