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Efeitos do consumo de ácidos graxos n-3, n-6 e trans sobre aspectos bioquímicos e moleculares em um modelo animal de mania
(Universidade Federal de Santa Maria, 2014-07-18)
Fatty acids (FA) are constituents of neuronal phospholipid membranes, where they are essential for the development and functioning of the brain. During the peak of neuronal growth, occurring during the last week of gestation ...
Ação protetora do licopeno sobre as alterações induzidas pela micotoxina zearalenona em camundongos machos
(Universidade Federal de Santa Maria, 2014-12-22)
Zearalenone (ZEA) an estrogenic mycotoxin and, therefore the reproductive system as one of its main targets of toxicity. Besides being a mycotoxin and toxigenic immunosuppressive, the ZEA hematological changes and promotes ...
Avaliação do perfil oxidativo e da atividade de ectoenzimas em pacientes com neoplasia intra-epitelial cervical
(Universidade Federal de Santa Maria, 2008-08-22)
Uterine cancers are considered to be one of the most important malignant diseases of the female genital tract, preceded only by breast cancer. The tumor cells may produce oxidative disturbances as well as damage to the ...
Polimorfismo da Ala16Val MnSOD na hipercolesterolemia e sua associação com biomarcadores de inflamação e estresse oxidativo
(Universidade Federal de Santa Maria, 2010-03-11)
This study aimed to analyze the association between the genetic polymorphism of the manganese-dependent superoxide dismutase (Ala16Val MnSOD) and the oxidative and inflammatory markers in hypercholesterolemic and control ...
Estudo de mecanismos de toxicidade do metilmercúrio: papel protetor de flavonóides
(Universidade Federal de Santa Maria, 2010-08-12)
Methylmercury (MeHg) is an important environmental toxicant that may cause irreversible neurobehavioral and neuropsychological disorders in humans and experimental animals. The major mechanisms of MeHg-induced toxicity ...
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2011-03-18)
Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still ...
Sistemas purinérgico e colinérgico e perfil oxidativo no encéfalo de roedores: influência do alumínio e de diferentes dietas
(Universidade Federal de Santa Maria, 2008-03-05)
In this study, the effects of Aluminium (Al) and of different diets, both individually and in association, were investigated through the determination of NTPDase, 5 -nucleotidase and acetylcholinesterase (AChE) activities ...
Efeitos da quercetina na atividade da cetilcolinesterase, na peroxidação lipídica e nos testes comportamentais em ratos diabéticos induzidos por estreptozotocina
(Universidade Federal de Santa Maria, 2013-02-28)
Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia, is a chronic condition that arises when the pancreas does not produce enough insulin or when the body can ...
Contribuições para o uso de células estromais mesenquimais no reparo de feridas cutâneas e no transplante de pele em coelhos
(Universidade Federal de Santa Maria, 2014-03-14)
This thesis was carried out in three distinct stages; the first being intended to analyzing the cell therapy of skin wound healing in rabbits. The aim of this work was to evaluate the healing potential of the stromal ...
Infecção experimental por Herpesvírus bovino tipo 5 em coelhos: efeitos no sistema purinérgico e perfil oxidativo
(Universidade Federal de Santa Maria, 2015-02-12)
The neurological disorder caused by BoHV-5 replication in the brain of infected animals, in the acute phase, may not be associated with significant histological changes or a significant number of antigen-positive neurons. ...