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Mecanismos envolvidos nos efeitos do seleneto vinílico bis substituído (svbs) em modelos animais de depressão e de dor
(Universidade Federal de Santa Maria, 2011-03-18)
The association between depression and chronic pain is frequent and bidirectional. The high number of patients with depression and chronic pain who are refractory to currently available drugs makes it important search for ...
A influência do processo inflamatório nas convulsões e no déficit cognitivo induzidos pelo ácido glutárico em ratos jovens
(Universidade Federal de Santa Maria, 2011-02-04)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM), characterized biochemically by major accumulation of glutaric acid (GA) and pathologically by a characteristic striatal degeneration. The clinical ...
Avaliação toxicológica de compostos orgânicos de telúrio sobre o desenvolvimento pré-natal em camundongos
(Universidade Federal de Santa Maria, 2011-03-25)
It is known that most chemical agents readily cross the placenta and thus may be considered that maternal exposure to external agents can result in toxic effects on embryo-fetal organism. Considering the chemical characteristics ...
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2011-03-18)
Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still ...
Envolvimento do sistema da tiorredoxina nas alterações induzidas pelo chumbo in vitro e in vivo: implicações na toxicidade do chumbo
(Universidade Federal de Santa Maria, 2011-11-30)
Oxidative stress is an important molecular mechanism of lead (Pb) toxicity. The thioredoxin
system (selenoenzyme thioredoxin reductase-TrxR, thioredoxin protein- Trx and NADPH) is essential
for the antioxidant defense ...
Educação ambiental objetiva para os níveis de ensinos: fundamental e médio
(Universidade Federal de Santa Maria, 2011-06-27)
The paper has the main goal presents the two levels of instruction: Elementary and High School in Santa Maria city, Rio Grande do Sul State, proposed curricula focused on Environmental Education objectivity as well a ...
Avaliação do disseleneto de difenila e análogos como substratos da tioredoxina redutase
(Universidade Federal de Santa Maria, 2011-07-15)
Since the successful use of the organoselenium compound ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there have been concerted efforts geared towards ...
Do gene à proteína: explorando o GenBank com alunos do ensino médio
(Universidade Federal de Santa Maria, 2011-06-07)
This study reports on the use of the Didactic Unit (DU): Exploring the GenBank
with high school students, which involved 20 school hours with a group of 06
volunteer students from the 2nd year of high school at the ...
O aborto como um problema de saúde pública: contribuições para o debate nas áreas da saúde e educação
(Universidade Federal de Santa Maria, 2011-10-21)
Abortion is a present subject since earlier times and the interest in such subject increases as years pass, since it is a multidisciplinary issue with a relevant importance. Nowadays, abortion represents a serious issue ...
A melhora da memória induzida por espermidina envolve a fosforilação da pkc, pka e creb em hipocampo de ratos
(Universidade Federal de Santa Maria, 2011-09-08)
The endogenous poliaminas, putrescine, spermidina and spermine are aliphatics amines that are present in high concentrations in the central nervous system (SNC). The action of the poliamines involves the modulation of ...