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Uncaria tomentosa: adjuvante no tratamento do câncer de mama
(Universidade Federal de Santa Maria, 2013-04-19)
Cat s Claw (Uncaria tomentosa) is a medicinal plant that has been used in the treatment of different diseases, among them, cancer. Studies show its effects in restoring the cellular DNA, in increasing leukocyte fractions, ...
Avaliação do perfil de resposta imune e da expressão dos receptores P2X7, P2Y11 e A2A na forma indeterminada da doença de Chagas
(Universidade Federal de Santa Maria, 2016-08-26)
Most infected individuals by protozoan Trypanosoma cruzi is in the indeterminate form of Chagas disease (IFCD), which is characterized by the presence of a tissue inflammatory infiltrate composed by mononuclear cells which ...
Avaliação do efeito da Uncaria tomentosa sob o sistema purinérgico em linhagens de câncer de mama
(Universidade Federal de Santa Maria, 2016-10-07)
The Uncaria tomentosa (UT), or cat's claw, is a perennial plant, native to Central and South America, rich in oxindole alkaloids and their precursors, indole alkaloids. For this plant have been assigned many biological ...
Avaliação do disseleneto de difenila e análogos como substratos da tioredoxina redutase
(Universidade Federal de Santa Maria, 2011-07-15)
Since the successful use of the organoselenium compound ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there have been concerted efforts geared towards ...
Ação neuroprotetora do composto ebselen e do exercício físico em modelos de doença de Alzheimer esporádica em camundongos
(Universidade Federal de Santa Maria, 2019-02-22)
Alzheimer's Disease (AD) is a neurodegenerative disease that reaches about 47 million people
in the world and this prevalence is expected to increase over the next two decades. A range of
evidence has shown that ...
Desbalanço superóxido-peróxido de hidrogênio versus seleno-L-metionina e castanha-do-Brasil: regulação diferencial in vitro de (seleno)enzimas
(Universidade Federal de Santa Maria, 2017-08-01)
Introduction: The coupled enzymatic reactions between the manganese-dependent superoxide dismutase (MnSOD/SOD2) and selenoenzyme glutathione peroxidase-1 (GPx-1) selenoenzyme are essential for mitochondrial redox balance ...
Efeito do suco de uva (vitis labrusca, bordô) sobre indicadores fisiopatológicos e bioquímicos da síndrome aguda da radiação em ratos wistar
(Universidade Federal de Santa Maria, 2010-03-03)
Exposure to radiation has toxic effects and for this reason research on food or drugs with positive radiomodifying action (protective) is of outmost interest to Public Health and Consumer Protection. Thus, the aim of this ...
Estudo da toxicidade induzida por metilglioxal em células sanguíneas humanas: efeito protetor do Syzigium cumini
(Universidade Federal de Santa Maria, 2017-09-01)
Methylglyoxal (MG) is a α-oxoaldehyde compound formed mainly as co-product from
glycolysis. Due its high glicative capacity, it is considered the major precursor of advanced
glycation end-products (AGEs). Although the ...
Efeito do ácido clorogênico, cafeína e café nas alterações oxidativas e no sistema purinérgico de ratos diabéticos induzidos por estreptozotocina
(Universidade Federal de Santa Maria, 2016-11-04)
Studies show that hyperglycemia in diabetes leads to complications in different tissues, mainly caused by the increased production of reactive oxygen species (ROS). The chlorogenic acid is a phenolic compound found in ...
A melhora da memória induzida por espermidina envolve a fosforilação da pkc, pka e creb em hipocampo de ratos
(Universidade Federal de Santa Maria, 2011-09-08)
The endogenous poliaminas, putrescine, spermidina and spermine are aliphatics amines that are present in high concentrations in the central nervous system (SNC). The action of the poliamines involves the modulation of ...