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Itens para a visualização no momento 101-110 of 247
Mecanismos de ação do resveratrol na diferenciação neural in vitro e na sinalização purinérgica em camundongos infectados com Toxoplasma gondii
(Universidade Federal de Santa Maria, 2018-09-24)
Central nervous system (CNS) development involves events that include the proliferation of neural precursor cells (NPCs) that differentiate and migrate in a process for creating connections and networks. In this context ...
Privação de sono em Drosophila melanogaster resulta em alterações na homeostase redox, mitocondrial e na expressão gênica de reguladores da função circadiana e metabólica
(Universidade Federal de Santa Maria, 2019-08-29)
Sleep deprivation and related diseases, such as metabolic disorders, are consequences of the
busy lifestyle of modern society. Sleep is a crucial resting state for survival and regulated by
circadian rhythms. Changes in ...
Efeito da silimarina e silibinina sobre as alterações comportamentais e neuroquímicas induzidas por 6-hidroxidopamina em camundongos
(Universidade Federal de Santa Maria, 2018-10-11)
Parkinson's disease (PD) is a disabling neurodegenerative disease that affects about 1-2% of the world's population. L-dopa is the most used treatment to attenuate the symptoms of PD; however, in the long term this drug ...
Envolvimento das cininas na dor do tipo fibromialgia induzida por reserpina e o efeito dos inibidores da enzima conversora de angiotensina I em camundongos
(Universidade Federal de Santa Maria, 2019-03-29)
Fibromyalgia is a chronic disease potentially disabling, characterized by widespread pain and a range of comorbidities as hypertension, besides not having specific pathophysiology or appropriate treatment. Evidence has ...
Guanosina modula a funcionalidade e a bioenergética mitocondrial em ratos
(Universidade Federal de Santa Maria, 2019-03-29)
Mitochondrial dysfunction is associated with a wide variety of degenerative and metabolic
diseases, cancer and aging. All these clinical manifestations result from problems in the
mitochondria in ...
Investigação experimental de fatores que modificam parâmetros de dependência e recaída por anfetamina
(Universidade Federal de Santa Maria, 2019-02-01)
Amphetamine (AMPH) is a psychostimulant drug able to modify the neuroplasticity of areas related to
the reward system; for instance, the mesocorticolimbic system. Besides the factors linked to the drug
itself, addictive ...
Estresse pré e pós natal afetam aspectos morfológicos, bioquímicos e moleculares do eixo cortico-hipotalâmico na prole adulta
(Universidade Federal de Santa Maria, 2019-10-18)
According to the World Health Organization (2010), stress is recognized and identified as the evil of the century due to its chronicity and repercussions that are directly connected to life quality, family and society. ...
Alterações comportamentais mediadas pelo etanol em peixe-zebra: influência do estresse oxidativo, disfunção mitocondrial e modulação serotoninérgica
(Universidade Federal de Santa Maria, 2020-07-24)
Ethanol consumption is a serious public health problem due to the negative impacts that affect individuals and society. Because the mechanism of action of ethanol in the central nervous system is complex and not fully ...
Dano ao DNA induzido por fotoclivagem e análise citotóxica de uma porfirina meso-tetra-rutenada sob irradiação por luz visível
(Universidade Federal de Santa Maria, 2020-12-03)
Photodynamic Therapy (PDT) combined with the use of molecules containing the porphyrin ring associated with ruthenium transition metal has become an alternative method to the traditional treatment of melanoma. Here, we ...
Estudos in silico aplicados a compostos orgânicos de mercúrio e selênio em sistemas biológicos
(Universidade Federal de Santa Maria, 2020-08-10)
Methylmercury (MeHg) is a potent neurotoxin, which is associated with the inhibition of Glutathione Peroxidase (GPx) and Thioredoxin Reductase (TrxR) selenozymes, however, the mechanism of MeHg inhibition, at the molecular ...