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Avaliação da barata Nauphoeta cinerea como organismo modelo para o estudo de sepse
(Universidade Federal de Santa Maria, 2020-11-05)
Studies using model organisms, such as insects, are growing and have sought to investigate, in
a preliminary way, the mechanisms involved in the progression of infectious diseases,
examine potential pharmacological targets ...
Envolvimento dos receptores NMDA e imidazolínicos nos efeitos das poliaminas sobre a preferência condicionada por lugar induzida por morfina
(Universidade Federal de Santa Maria, 2020-01-30)
Morphine use disorder is a chronic disease involving biological, cognitive and behavioral changes that develop
after repeated and compulsive substance use. Even after long periods of abstinence relapses occur to ...
Mecanismos de toxicidade de Duguetia furfuraceae A. St.-Hill no modelo de Drosophila melanogaster e avaliação do potencial antifúngico.
(Universidade Federal de Santa Maria, 2015-12-04)
Duguetia furfuracea is a common shrub from Brazilian cerrado areas, known as "ata brava", often used as a medicinal plant especially in treatment of renal colic and rheumatism. However, pharmacological studies with extracts ...
Modelagem do fenótipo de diabetes em Nauphoeta cinerea usando estreptozotocina: Foco no metabolismo da glicose no cérebro
(Universidade Federal de Santa Maria, 2021-05-16)
The brain is highly dependent on adequate glucose catabolism, but changes in brain glucose transport are well documented in hyperglycemic conditions. Recent evidence of “hyperglycemic memory" further suggests that chronic ...
Respostas bioquímicas em carpas (Cyprinus carpio) expostas a duas formulações comerciais de inseticidas em condições de lavoura de arroz e em laboratório
(Universidade Federal de Santa Maria, 2012-07-27)
The pesticides are substances widely used in agriculture, because it enhances productivity. However, its excessive and disordered use has caused different impacts on the environment. Therefore, this study investigated the ...
Papel da vitamina D3 em doenças neurológicas e avaliação pré-clinica na demência esporádica do tipo Alzheimer
(Universidade Federal de Santa Maria, 2019-09-06)
Dementia is a brain disorder characterized by decline of some function, resulting in deficits in memory functioning and in dialy cognitive tasks. Evidence has emerged that Vitamin D3 (VD3) has innumerable functions in the ...
Efeito neuroprotetor da Berberina na neurotoxicidade induzida por estreptozotocina e lipolissacarídeo em ratos
(Universidade Federal de Santa Maria, 2019-10-29)
Alzheimer's disease (AD) is considered the major cause of dementia and is characterized by changes in the cholinergic and purinergic system, oxidative stress, inflammatory process and metabolic changes that, in turn, are ...
Silimarina modifica a atividade da Na+/K+-ATPase e da MAO e modula a ação de antimicrobianos in vitro
(Universidade Federal de Santa Maria, 2015-06-10)
The Silymarin is a flavonolignan complex isolated from milk thistle seeds of Silybum marianum being used in the treatment of injury related to oxidative stress, including liver and neurological diseases, as Parkinson ...
Síntese e atividades antioxidante e antitumoral de 5´-arilseleno azidotimidina
(Universidade Federal de Santa Maria, 2012-03-30)
The synthesis of compounds that use a nucleoside as the base structure, has an intense field application. Among these compounds, the most known nowadays is azydothymidine or zidovudine, a drug which was first synthesized ...
Estudos teóricos e de modelagem molecular in silico aplicados à interação entre a enzima delta-aminolevulinato desidratase e disselenetos de diarila
(Universidade Federal de Santa Maria, 2013-05-06)
Delta-aminolevulinic acid dehydratase (δ-ALA-D) is an essential metalloprotein found in several biological processes, since it is able to catalyze the formation of porphobilinogen (PBG), a precursor monopyrol of tetrapyrroles ...