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Dano ao DNA no diabetes tipo 2 e sua associação com inflamação, estresse oxidativo, disfunção endotelial, resistência à insulina e à ocorrência de complicações crônicas microvasculares
(Universidade Federal de Santa Maria, 2016-03-15)
Several pathophysiological mechanisms are associated with type 2 diabetes mellitus (type 2 DM), such as glucotoxicity, insulin resistance, inflammation, oxidative stress and endothelial dysfunction, which can result in DNA ...
Determinação de HPAs presentes na nutrição parenteral e avaliação da exposição de neonatos através da presença do 1-hidroxipireno na urina
(Universidade Federal de Santa Maria, 2016-10-19)
Carbon black, which has polycyclic aromatic hydrocarbons (PAHs) adsorbed
on its surface, is used in the composition of rubber for pharmaceutical used in
injectable drugs and parenteral formulations such as amino acid ...
INVESTIGAÇÃO LABORATORIAL DA NEFROPATIA DIABÉTICA: AVALIAÇÃO DE MARCADORES TUBULARES E DO IMPACTO DA CORREÇÃO PELA CREATININA URINÁRIA
(Universidade Federal de Santa Maria, 2014-10-31)
Diabetic nephropathy (DN) is a multifactorial patholgy, characterized by the increased presence of albumin in urine. Currently, urinary albumin (uAlb) is a marker for glomerular damage mostly used for the diagnosis of DN; ...
Avaliação da atividade de enzimas que degradam nucleotídeos de adenina e do perfil oxidativo em ratos com sepse induzida
(Universidade Federal de Santa Maria, 2014-07-30)
Sepsis is recognized as a systemic inflammatory response (SIRS) to infection with the
presence of progressive tissue damage, where multiple organ failure is the most severe
expression. The purinergic signaling plays an ...
Caracterização molecular de Echinococcus spp. em bovinos no Rio Grande do Sul e avaliação in vitro e ex vivo do óleo de Melaleuca alternifolia frente aos protoescóleces de Echinococcus ortleppi
(Universidade Federal de Santa Maria, 2016-03-04)
Cystic echinococcosis (CE) is a zoonotic disease caused by Echinococcus genus. The larval stage (hydatid cyst) of the parasite causes serious public health problems, and affects various species of animals, causing economic ...
Atividades biológicas, isolamento de compostos ativos e caracterização de extratos obtidos de Scutia Buxifolia Reissek.
(Universidade Federal de Santa Maria, 2014-03-20)
Scutia buxifolia Reissek belongs to the Rhamnaceae family and is popularly known as
coronilha. The stem bark infusion is popularly used as cardiotonic, antihypertensive and
diuretic. This work aims to determine the ...
Avaliação da potência do hormônio da paratireóide humano recombinante por bioensaio, métodos cromatográficos e eletroforético
(Universidade Federal de Santa Maria, 2017-05-24)
The human parathyroid hormone (hPTH) is a polypeptide secreted by the parathyroid glands that is essential for the maintenance of the calcium ion homeostasis in the blood. The recombinant DNA technology has enabled the ...
Avaliação de potenciais biomarcadores séricos e salivares e do polimorfismo do gene da glutationa S-transferase P1 (GSTP1) na obesidade adulto jovem
(Universidade Federal de Santa Maria, 2015-11-20)
Obesity and overweight are complex clinical syndromes responsible for high morbidity and
mortality throughout the world, as they are risk factors for the development of Metabolic
Syndrome, diabetes mellitus, dyslipidemia, ...
Estudos analíticos para caracterização e avaliação de interleucina-11 humana recombinante
(Universidade Federal de Santa Maria, 2015-12-04)
Interleukin 11 (IL-11) is an endogenous cytokine that directly stimulates the proliferation of hematopoietic stem cells and megakaryocytic progenitor cells and induces megakaryocytic maturation. With advances in biotechnology, ...
Avaliação das metodologias de detecção bacteriana e de resistência dos Staphylococcus coagulase negativa isolados das bolsas de concentrados plaquetários
(Universidade Federal de Santa Maria, 2015-05-22)
Platelet transfusion therapy has played an important role in the treatment of patients with hematological and oncological diseases. However, platelet transfusion represents a risk for bacterial sepsis. Platelet Concentrates ...