Several pathophysiological mechanisms are associated with type 2 diabetes mellitus (type 2 DM), such as glucotoxicity, insulin resistance, inflammation, oxidative stress and endothelial dysfunction, which can result in DNA ...

Carbon black, which has polycyclic aromatic hydrocarbons (PAHs) adsorbed on its surface, is used in the composition of rubber for pharmaceutical used in injectable drugs and parenteral formulations such as amino acid ...

Diabetic nephropathy (DN) is a multifactorial patholgy, characterized by the increased presence of albumin in urine. Currently, urinary albumin (uAlb) is a marker for glomerular damage mostly used for the diagnosis of DN; ...

Sepsis is recognized as a systemic inflammatory response (SIRS) to infection with the presence of progressive tissue damage, where multiple organ failure is the most severe expression. The purinergic signaling plays an ...

Cystic echinococcosis (CE) is a zoonotic disease caused by Echinococcus genus. The larval stage (hydatid cyst) of the parasite causes serious public health problems, and affects various species of animals, causing economic ...

Scutia buxifolia Reissek belongs to the Rhamnaceae family and is popularly known as coronilha. The stem bark infusion is popularly used as cardiotonic, antihypertensive and diuretic. This work aims to determine the ...

The human parathyroid hormone (hPTH) is a polypeptide secreted by the parathyroid glands that is essential for the maintenance of the calcium ion homeostasis in the blood. The recombinant DNA technology has enabled the ...

Obesity and overweight are complex clinical syndromes responsible for high morbidity and mortality throughout the world, as they are risk factors for the development of Metabolic Syndrome, diabetes mellitus, dyslipidemia, ...

Interleukin 11 (IL-11) is an endogenous cytokine that directly stimulates the proliferation of hematopoietic stem cells and megakaryocytic progenitor cells and induces megakaryocytic maturation. With advances in biotechnology, ...

Platelet transfusion therapy has played an important role in the treatment of patients with hematological and oncological diseases. However, platelet transfusion represents a risk for bacterial sepsis. Platelet Concentrates ...