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Resistência de biofilmes formados por micobactérias de crescimento rápido frente a antimicrobianos
(Universidade Federal de Santa Maria, 2018-03-28)
Rapidly growing mycobacteria (RGM) are opportunistic pathogens that produce diseases in a variety of clinical settings. The environmental nature of RGM and their ability to assemble biofilms on different surfaces play a ...
Análise cromatográfica e eletroforética de fármacos em suplementos alimentares e avaliação de interações medicamentosas in silico
(Universidade Federal de Santa Maria, 2018-03-02)
The increased demand for dietary supplements in recent years leads to an alarming scenario regarding the efficacy and safety of these products. The lack of a specific category for registration of these products leads to ...
Efeito da quercetina na sinalização purinérgica e no metabolismo oxidativo-inflamatório em modelo de artrite
(Universidade Federal de Santa Maria, 2018-12-17)
Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease with predominant
involvement of the small joints, progressive destruction of cartilage and bone, and extra-
articular manifestations ...
Avaliação dos índices plaquetários, atividade da e-ntpdase e da ecto-5'-nucleotidase em plaquetas de gestantes normotensas e com pré-eclâmpsia
(Universidade Federal de Santa Maria, 2018-08-28)
Preeclampsia is the most common medical complication in pregnancy, accounting for the main cause of
maternal and perinatal mortality and morbidity. Its etiology remains unknown which makes primary
prevention difficult. ...
Sistemas de base nanotecnológica contendo disseleneto de difenila para o tratamento do melanoma e do glioma
(Universidade Federal de Santa Maria, 2018-08-31)
Cancer is one of the diseases with the highest mortality in Brazil and worldwide. In addition, the conventional therapies present low efficacy and high toxicity. In this context, the diphenyl diselenide [(PhSe)2], an ...
Modelo PAMPA para estudo comparativo da permeabilidade de compostos fenólicos isolados e a partir de extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2018-08-29)
The use of natural compounds from the Brazilian national flora provides the population
access to treatment of various disorders and the development of new therapeutic
products. Therefore, it is important that permeation ...
Desenvolvimento e avaliação biofarmacêutica de supositórios de doxiciclina hiclato para uso veterinário
(Universidade Federal de Santa Maria, 2018-08-17)
Veterinary drug therapy can be quite laborious especially when performed in the home environment. Usually the animal drug treatment is done by the oral or injectable route, but the rectal route can be an alternative. The ...
Desenvolvimento e avaliação biológica de preparações nanoestruturadas de desonida para uso tópico
(Universidade Federal de Santa Maria, 2018-08-27)
Topical corticosteroid are widely used in dermatology. However, the therapy with these drugs
has some limitations related to the treatment duration and to drug potency, that may cause
undesirable effects. Nanoparticulate ...
Atividade farmacológica da tintura das folhas de Baccharis trimera (LESS)
(Universidade Federal de Santa Maria, 2018-08-16)
The plant belongs to the family Asteraceae, Baccharis trimera (Less) DC is a small tree, found in rocky soils and sandy fields of southern Brazil, Paraguay, Uruguay and Argentina and, in these places, it is popularly known ...
Atividade antibacteriana e antibiofilme de complexos de sulfa e ouro contra bactérias gram-negativas e gram-positivas
(Universidade Federal de Santa Maria, 2018-10-26)
Antibiotic resistance develops as a natural consequence of the bacterial population's ability to adapt. In addition, the indiscriminate use of antibiotics has been considered as one of the factors that predispose the ...