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Envolvimento dopaminérgico na modulação da resposta de estresse em peixes-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2019-06-03)
The dopaminergic system is the subject of numerous researches due to its complexity and to have numerous pathways and receptors in the central nervous system. The release of catecholamines such as dopamine and norepinephrine, ...
Bioacumulação e parâmetros de estresse oxidativo em Tambaqui (Colossoma macropomum) exposto a MnCl2 em diferentes níveis de oxigênio dissolvido
(Universidade Federal de Santa Maria, 2013-04-18)
The aquatic organisms are susceptible to frequent interferences in their habitat, such
as oxygen fluctuations and metal contamination. Industrial production and oil
exploration, among other activities, release manganese ...
Exposição a agroquímicos altera o funcionamento do eixo hipotálamo-hipófise-interrenal em zebrafish
(Universidade Federal de Santa Maria, 2017-08-21)
The increase of human occupation in rural areas and the intensification of agricultural practices produces increasingly agrochemical waste up to aquatic ecosystems. Based on this, many studies are needed to clarify the ...
Montelucaste diminui as crises convulsivas em animais abrasados e potencializa o efeito anticonvulsivante do fenobarbital
(Universidade Federal de Santa Maria, 2015-07-28)
Epilepsy is a chronic neurological disease characterized by recurrent, unprovoked seizures. Evidence suggests that inflammation plays a role in the pathophysiology of seizures. Although cysteinyl leukotrienes (CysLTs) have ...
Modulação gênica dos receptores de prostaglandina E2 em células miometriais e cervicais em partos induzidos com prostaglandinas: estudo in vivo e in vitro
(Universidade Federal de Santa Maria, 2015-09-18)
The mechanisms involved in human parturition, and the molecular changes that occur during the transition from pregnancy and birth are not completely elucidated. Endogenous or administered prostaglandins, including the PGE1 ...
Potencial terapêutico do extrato metanólico de Condalia buxifolia reissek no controle da dor aguda: estudo do mecanismo de ação
(Universidade Federal de Santa Maria, 2015-08-06)
The medicinal plant Condalia buxifolia has been traditionally used to treat inflammatory processes. The present study aimed to evaluate the phytochemical profile and the analgesic effect of the methanolic extract from the ...
Efeito do resveratrol e da vitamina E frente a prejuízos reprodutivos causados pelo uso de ácido valpróico em ratos machos
(Universidade Federal de Santa Maria, 2016-08-31)
Long-term treatment with valproic acid (VPA) has been associated with adverse effects
on the male reproductive function mediated by increased testicular oxidative stress.
Thus, this study evaluated the potential protective ...
Envolvimento dos receptores CysLT1 nas crises induzidas por pentilenotetrazol em camundongos, na permeabilidade da barreira hematoencefálica e na modulação da enzima na+,k+-ATPase em hipocampo
(Universidade Federal de Santa Maria, 2014-08-23)
Growing evidence has shown that leukotrienes are important contributors in the pathophysiology of several SNC inflammatory diseases where excitotoxicity is involved, including traumatic brain injury, encephalitis, Parkinson's ...
Uso da combinação de cetamina e metadona no tratamento da dor neuropática causada por diferentes etiologias clínicas
(Universidade Federal de Santa Maria, 2013-04-27)
Methadone and ketamine have been used in neuropathic pain management, but the benefits of the association of both drugs are uncertain. Aiming to enhance the analgesic efficacy and to reduce the occurrence of adverse-effects, ...
Potencial antidepressivo e analgésico do 2-(3,4-dimetoxi-fenil)-4,5-diidro-1H-imidazol (2-DMPI) em camundongos
(Universidade Federal de Santa Maria, 2012-12-18)
Depression and chronic pain coexist in several patients and may be modulated by the same neurotransmitter systems. In this context, various studies have demonstrated that antidepressants from the class of the inhibitors ...