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Efeito do desbalanço genético e farmacológico do metabolismo oxidativo em indicadores de fertilidade masculina
(Universidade Federal de Santa Maria, 2016-12-07)
Previous studies indicate that changes in oxidative metabolism may play a role in reproductive
success. Manganese-dependent superoxide dismutase enzyme (SOD2), a key in the oxidative
balance, presents a genetic variation ...
Efeitos de inibidores da enzima COX-2 sobre o desenvolvimento de crises convulsivas em camundongos
(Universidade Federal de Santa Maria, 2018-01-12)
Cyclooxygenase-2 (COX-2) inhibitors reduce the synthesis of prostaglandins (PGs) and play an important role in inflammation. In the last decades, research has been focused on the use of COX-2 inhibitors and the inflammatory ...
Influência de Harpagophytum procumbens sobre parâmetros comportamentais e moleculares em um modelo de discinesia orofacial em ratos
(Universidade Federal de Santa Maria, 2017-02-18)
Fluphenazine is a typical antipsychotic used for the treatment of schizophrenia. However, its chronic use has been related to the appearance of extrapyramidal side effects, such as tardive dyskinesia (TD). Studies suggest ...
Potencial antidepressivo do extrato aquoso de Ilex paraguariensis em roedores: envolvimento do sistema monoaminérgico
(Universidade Federal de Santa Maria, 2017-03-31)
Ilex paraguariensis is a plant largely consumed in South America as an infusion known as ―chimarrão‖ or ―mate‖, which shows effects related to its action in the central nervous system. However, little is known about its ...
O efeito neuroprotetor da Espermina em condições de inflamação ocorre via BDNF, ativação do receptor TrkB, CREB e alteração na neurogênese
(Universidade Federal de Santa Maria, 2019-06-11)
Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and disrupting memory pathway and neurogenesis. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS ...
Gabapentina previne alterações comportamentais induzidas por anfetamina ou haloperidol em camundongos
(Universidade Federal de Santa Maria, 2017-12-19)
Schizophrenia is a chronic and highly complex psychiatric illness that manifests with a wide spectrum of changes that include cognitive, negative and positive symptoms. The drugs available for the treatment (antagonists ...
Interação entre o brometo de piridostigmina e o desbalanço superóxido-peróxido de hidrogênio na cito-genotoxicidade de células neurais e imunes mononucleares
(Universidade Federal de Santa Maria, 2018-06-11)
Pyridostigmine bromide (PB) is a reversible acetylcholinesterase inhibitor (AChE), and the first line of
symptoms associated with neuromuscular junction disorders (JNM) and has been used prophylactically
in the Persian ...
Suscetibilidade in vitro a antifúngicos, frações de óleos essenciais e modelo experimental de infecção por Malassezia pachydermatis
(Universidade Federal de Santa Maria, 2018-07-19)
Malassezia pachydermatis is a zoophilic yeast mainly found in the auditory canal of various animal species, and may also be isolated from the skin of humans. Azole and polyene antifungals are the treatment of choice for ...
Citral como aditivo na dieta de peixes estuarinos: perfil redox, imunidade inata e parâmetros hepáticos
(Universidade Federal de Santa Maria, 2019-06-27)
Citral is a monoterpenoid that occurs in essential oils of different plant species used in folk medicine, which also showed promising effects when added to fish diets. However, in spite of the numerous biological activities ...
Efeito da atorvastatina sobre as alterações comportamentais, histológicas e bioquímicas em camundongos C57BL/6 com status epilepticus induzido por pilocarpina
(Universidade Federal de Santa Maria, 2017-03-06)
Epilepsy is a chronic neurological disease that affects 65 million people worldwide. Temporal
lobe epilepsy (TLE) is the most common type of focal epilepsy in adults, and also the one
with the highest refractoriness index ...