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Atividade radioprotetora, perfil toxicológico e efeito contra a toxicidade da ciclofosfamida do extrato de tucumã: estudos in vitro e in vivo
(Universidade Federal de Santa Maria, 2020-08-04)
Cancer is a multifactorial disease characterized by loss of control of cell division. Nowadays, it is a serious health problem worldwide, leading to many deaths every year. Current treatments for cancer include radiation ...
Avaliação dos efeitos de curcumina e silimarina sobre a toxicidade induzida por micotoxinas in vitro e in vivo
(Universidade Federal de Santa Maria, 2020-10-08)
Mycotoxins are secondary metabolites produced by fungi and represent a worldwide concern
due to their global distribution and the harmful effects caused by their ingestion. This problem
presents itself in its most dramatic ...
Estresse oxidativo e metabolismo ósseo em modelo roedor de síndrome dos ovários policísticos (SOP)
(Universidade Federal de Santa Maria, 2020-12-18)
Polycystic ovary syndrome (PCOS) is considered the commonest cause of endocrine infertility in women and affects around 8% of females at reproductive age. It is a complex disturbance, frequently associated with insulin ...
Avaliação da atividade antinociceptiva do extrato e do alcaloide s-(+)-dicentrina extraído de frutos de Ocotea puberula (Lauraceae)
(Universidade Federal de Santa Maria, 2012-12-18)
Ocotea puberula (Lauraceae) is a brazilian native tree, known in the South regions as canela guaicá or canela amarela. Its phytochemical composition includes several alkaloids of aporphinic type, some of them with biological ...
Avaliação das propriedades farmacológicas e farmacogenéticas do extrato e frações da planta Pavonia xanthogloea (Malvaceae)
(Universidade Federal de Santa Maria, 2014-01-31)
The Pampa Biome has a great biodiversity of plants, among them the Family Malvaceae. Despite the medicinal use of many of these plants, studies on the biological activity of these are still very scarce. This is the case ...
A ação anti-inflamatória do lítio é influenciada por fatores genéticos, nutricionais e fármacos antidepressivos: estudos in vitro
(Universidade Federal de Santa Maria, 2017-09-01)
Population aging has increased the prevalence of chronic non-communicable diseases, including psychiatric disorders such as depression and bipolar spectrum disorders (BSDs). Evidence suggests that such disorders are ...
Efeito do antipsicótico haloperidol em Caenorhabditis elegans e do extrato bruto de Piper methysticum em camundongos sobre parâmetros comportamentais e bioquímicos
(Universidade Federal de Santa Maria, 2021-08-31)
Psychotic disorders, as schizophrenia and substance-induced psychoses (amphetamine, for example), are characterized by the appearance of delusions, hallucinations and other, and their symptoms are associated with hyperactivation ...
Farmacocinética de S-(+)-linalol em jundiás (Rhamdia quelen)
(Universidade Federal de Santa Maria, 2021-06-18)
S-(+)-linalool is found in essential oils of aromatic plants as Lippia alba. This phytochemical had its sedative/anesthetic activity elucidated in Rhamdia quelen, popularly known as silver catfish. Thus, S-(+)-linalool has ...
Suscetibilidade in vitro de Prototheca spp., isoladas de leite bovino, aos óleos essenciais, aos peptídeos e fármacos antimicrobianos
(Universidade Federal de Santa Maria, 2021-03-19)
Alchlorophilic algae of the genus Prototheca are disease-causing agents in humans and animals. The species Prototheca zopfii (genotype 2), with recent reclassification suggested for P. bovis, is cited by several authors ...
Fraturas ósseas em mulheres na pós-menopausa: um estudo de coorte em Santa Maria/RS
(Universidade Federal de Santa Maria, 2021-03-31)
Osteoporosis is characterized by low bone mass associated with abnormalities in bone microarchitecture, increasing the risk of fragility fractures. Although there are guidelines for the diagnosis and treatment of osteoporosis, ...