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O efeito neuroprotetor da Espermina em condições de inflamação ocorre via BDNF, ativação do receptor TrkB, CREB e alteração na neurogênese
(Universidade Federal de Santa Maria, 2019-06-11)
Lipopolysaccharide (LPS) has been long known to promote neuroinflammation and disrupting memory pathway and neurogenesis. Since spermine, one of the main natural polyamines in the central nervous system, protects from LPS ...
Desenvolvimento de nanocápsulas poliméricas contendo Indol-3-Carbinol e avaliação biológica das formulações
(Universidade Federal de Santa Maria, 2016-08-08)
Indole-3carbinol (I3C) is a phytochemical that has several therapeutic properties. However, it is unstable
against acid and light conditions. In this sense, polymeric nanocapsules are interesting alternatives for
the ...
Citral como aditivo na dieta de peixes estuarinos: perfil redox, imunidade inata e parâmetros hepáticos
(Universidade Federal de Santa Maria, 2019-06-27)
Citral is a monoterpenoid that occurs in essential oils of different plant species used in folk medicine, which also showed promising effects when added to fish diets. However, in spite of the numerous biological activities ...
Papel do receptor B2 de cininas na patogênese e progressão da doença de Alzheimer experimental: da resposta imune à cognição
(Universidade Federal de Santa Maria, 2019-08-02)
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder
characterized by the decline and loss of cognitive functions, and it is the most common of
dementias. The major pathological features of ...
Influência da exposição ao modafinil sobre a preferência por anfetamina em diferentes períodos do desenvolvimento
(Universidade Federal de Santa Maria, 2019-11-22)
Addiction, which is characterized by the desire and the search for the drug, despite negative
consequences, is a serious health problem, causing impairments to the individual, your family, and
society. Thus, the developing ...
Ação protetora da Carya illinoensis sobre a toxicidade induzida por ciclofosfamida em ratos
(Universidade Federal de Santa Maria, 2010-01-29)
Cyclophosphamide (CP) is an alkylating agent widely used in anticancer and immunosuppression therapy. Like other chemotherapies, this drug can induce damage in healthy tissues, generating multiple organ toxicity. The study ...
Adição do óleo essencial de Lippia alba (Mill) N. E. Brown na dieta do jundiá: análise do crescimento e da resposta antioxidante
(Universidade Federal de Santa Maria, 2013-02-06)
Fish become more susceptible to stress and, consequently, to the onset of disease with the intensification of rearing. In an attempt to minimize this problem, farmers use agrochemicals that, besides harming the environment, ...
Nanopartículas contendo propionato de clobetasol: preparação, caracterização e incorporação em hidrogéis
(Universidade Federal de Santa Maria, 2010-03-29)
The aim of this work was the development of nanostructured formulations containing
clobetasol propionate. Initially, it was validated a chromatographic method to assay clobetasol
propionate in nanocapsule suspensions. ...
Caracterização molecular e prospecção de combinações antifúngicas sinérgicas “in vitro” frente a Trichosporon asahii, antes e após exposição prolongada ao fluconazol
(Universidade Federal de Santa Maria, 2016-11-17)
The occurence of invasive fungal infections caused by emerging fungal pathogens has increased considerably in the last decades. The genus Trichosporon comprises species relevant in this context, due to reduced susceptibility ...
Análise fitoquímica das raizes e folhas, e morfo-anatômica dos caules e folhas de Urera baccifera Gaudich
(Universidade Federal de Santa Maria, 2012-07-05)
The plant Urera baccifera Gaudich, known as stinging nettle, had its leaves and roots used to urinary infections and arthritis. Studies about its anti-inflammatory activities already exist, but are few the studies about ...