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Efeito da silimarina e silibinina sobre as alterações comportamentais e neuroquímicas induzidas por 6-hidroxidopamina em camundongos
(Universidade Federal de Santa Maria, 2018-10-11)
Parkinson's disease (PD) is a disabling neurodegenerative disease that affects about 1-2% of the world's population. L-dopa is the most used treatment to attenuate the symptoms of PD; however, in the long term this drug ...
Envolvimento das cininas na dor do tipo fibromialgia induzida por reserpina e o efeito dos inibidores da enzima conversora de angiotensina I em camundongos
(Universidade Federal de Santa Maria, 2019-03-29)
Fibromyalgia is a chronic disease potentially disabling, characterized by widespread pain and a range of comorbidities as hypertension, besides not having specific pathophysiology or appropriate treatment. Evidence has ...
Guanosina modula a funcionalidade e a bioenergética mitocondrial em ratos
(Universidade Federal de Santa Maria, 2019-03-29)
Mitochondrial dysfunction is associated with a wide variety of degenerative and metabolic
diseases, cancer and aging. All these clinical manifestations result from problems in the
mitochondria in ...
Investigação experimental de fatores que modificam parâmetros de dependência e recaída por anfetamina
(Universidade Federal de Santa Maria, 2019-02-01)
Amphetamine (AMPH) is a psychostimulant drug able to modify the neuroplasticity of areas related to
the reward system; for instance, the mesocorticolimbic system. Besides the factors linked to the drug
itself, addictive ...
Estresse pré e pós natal afetam aspectos morfológicos, bioquímicos e moleculares do eixo cortico-hipotalâmico na prole adulta
(Universidade Federal de Santa Maria, 2019-10-18)
According to the World Health Organization (2010), stress is recognized and identified as the evil of the century due to its chronicity and repercussions that are directly connected to life quality, family and society. ...
Neuroproteção do cassis (Ribes nigrum L.) e de sua associação com o Donepezil em modelo de amnésia induzida por escopolamina
(Universidade Federal de Santa Maria, 2019-12-13)
Memory deficits that occur with the process of aging could also be associated with the pathophysiology of neurodegenerative diseases, such as Alzheimer’s disease (AD). AD is characterized by the progressive deterioration ...
Efeito toxicológico em ninfas de Nauphoeta cineria (Blattodea:Blaberidae) expostas por inalação ao 4-vinilciclohexeno
(Universidade Federal de Santa Maria, 2019-10-28)
Exposure to numerous toxic agents, including occupational exposure to volatile organic
compounds has generated numerous health problems in humans, which are correlated
to the emergence of numerous diseases. The volatile ...
Mecanismos de toxicidade de Duguetia furfuraceae A. St.-Hill no modelo de Drosophila melanogaster e avaliação do potencial antifúngico.
(Universidade Federal de Santa Maria, 2015-12-04)
Duguetia furfuracea is a common shrub from Brazilian cerrado areas, known as "ata brava", often used as a medicinal plant especially in treatment of renal colic and rheumatism. However, pharmacological studies with extracts ...
Respostas bioquímicas em carpas (Cyprinus carpio) expostas a duas formulações comerciais de inseticidas em condições de lavoura de arroz e em laboratório
(Universidade Federal de Santa Maria, 2012-07-27)
The pesticides are substances widely used in agriculture, because it enhances productivity. However, its excessive and disordered use has caused different impacts on the environment. Therefore, this study investigated the ...
Papel da vitamina D3 em doenças neurológicas e avaliação pré-clinica na demência esporádica do tipo Alzheimer
(Universidade Federal de Santa Maria, 2019-09-06)
Dementia is a brain disorder characterized by decline of some function, resulting in deficits in memory functioning and in dialy cognitive tasks. Evidence has emerged that Vitamin D3 (VD3) has innumerable functions in the ...