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S. schenckii, S. luriei, S. brasiliensis e S. albicans: suscetibilidade a agentes antifúngicos combinados e caracterização de perfil enzimático
(Universidade Federal de Santa Maria, 2012-08-06)
Recently was proposed that Sporothrix schenckii is a complex encompassing six cryptic species, which calls for the reassessment of laboratory characteristics inherent susceptibility and virulence of this fungi complex. In ...
Avaliação do polimorfismo da Ala16ValMnSOD e dos parâmetros bioquímicos no déficit cognitivo na epilepsia
(Universidade Federal de Santa Maria, 2020-03-09)
Epilepsy is a chronic neurological condition, characterized by recurrent epileptic
seizures that can cause neurochemical, cognitive and psychological changes. The
mechanisms of action associated with epilepsy can involve ...
Influência do extrato de Curcuma longa (MOTORE®) sobre parâmetros bioquímicos e moleculares em jundiás (Rhamdia quelen) experimentalmente infectados com Aeromonas hydrophila
(Universidade Federal de Santa Maria, 2022-07-15)
This study aims to evaluate the effects of pre-treatment with purified extract of Curcuma longa (MOTORE®) on the development of oxidative stress in silver catfish (Rhamdia quelen) infected with Aeromonas hydrophila (MF ...
O papel do íon ferro nas infecções por Pythium insidiosum
(Universidade Federal de Santa Maria, 2014-01-30)
The oomycete Pythium insidiosum, classified in the kingdom Straminipila, is the agent of pythiosis, a chronic disease that can be hard to treat and life-threatening. The predisposing factors in mammals are unknown, but the ...
Resíduos de risperidona no ambiente: efeitos persistentes e transgeracionais
(Universidade Federal de Santa Maria, 2018-12-13)
Contamination of aquatic environments by pharmaceutical components is a growing concern. Little is known about the consequences of exposure to these chemical agents, especially during the early stages of development. ...
Envolvimento do receptor TRPA1 na nocicepção e neuroinflamação observada em modelos de esclerose múltipla em camundongos
(Universidade Federal de Santa Maria, 2022-05-03)
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), and neuropathic pain and headache are significant sensory alterations that are difficult to manage in these patients. In the different ...
Estudo experimental dos efeitos do canabidiol: possível estratégia para o tratamento da adição à anfetamina
(Universidade Federal de Santa Maria, 2022-02-04)
Amphetamine (AMPH) addiction is a chronic and relapsing disease caused by the compulsive drug seeking and
continued use despite harmful consequences. Currently, there is no effective and approved pharmacological
treatment ...
Formação de produtos proteicos de oxidação avançada a partir da reação de fenton e colágeno: efeitos sobre processos inflamatórios em neutrófilos e células renais embrionárias
(Universidade Federal de Santa Maria, 2016-07-05)
The advanced oxidation protein products (AOPPs) are a new class of compounds identified as markers of oxidative damage to proteins. The physiology role of these products is not limited to assess the oxidative stress, and ...
Influência do desbalanço superóxido-peróxido de hidrogênio na resiliência psico-comportamental: um estudo translacional
(Universidade Federal de Santa Maria, 2021-06-18)
Introduction: The psychosocial stress is considered a trigger in the development of several non-communicable
chronic diseases (NCDs), especially psychiatric disorders such as Depression. However, stressful events ...
Efeito do resveratrol nas alterações comportamentais induzidas por flufenazina em ratos e sua interação com a enzima monoaminoxidase in silico e in vitro
(Universidade Federal de Santa Maria, 2016-08-11)
Typical antipsychotics, commonly used to schizophrenia treatment, cause tardive dyskinesia in humans and
orofacial dyskinesia (OD) in rodents. In the present work, we investigated the effects of resveratrol, a polyphenol
with ...