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Modulação gênica dos receptores de prostaglandina E2 em células miometriais e cervicais em partos induzidos com prostaglandinas: estudo in vivo e in vitro
(Universidade Federal de Santa Maria, 2015-09-18)
The mechanisms involved in human parturition, and the molecular changes that occur during the transition from pregnancy and birth are not completely elucidated. Endogenous or administered prostaglandins, including the PGE1 ...
Potencial terapêutico do extrato metanólico de Condalia buxifolia reissek no controle da dor aguda: estudo do mecanismo de ação
(Universidade Federal de Santa Maria, 2015-08-06)
The medicinal plant Condalia buxifolia has been traditionally used to treat inflammatory processes. The present study aimed to evaluate the phytochemical profile and the analgesic effect of the methanolic extract from the ...
Efeito do resveratrol e da vitamina E frente a prejuízos reprodutivos causados pelo uso de ácido valpróico em ratos machos
(Universidade Federal de Santa Maria, 2016-08-31)
Long-term treatment with valproic acid (VPA) has been associated with adverse effects
on the male reproductive function mediated by increased testicular oxidative stress.
Thus, this study evaluated the potential protective ...
Envolvimento dos receptores CysLT1 nas crises induzidas por pentilenotetrazol em camundongos, na permeabilidade da barreira hematoencefálica e na modulação da enzima na+,k+-ATPase em hipocampo
(Universidade Federal de Santa Maria, 2014-08-23)
Growing evidence has shown that leukotrienes are important contributors in the pathophysiology of several SNC inflammatory diseases where excitotoxicity is involved, including traumatic brain injury, encephalitis, Parkinson's ...
Erva-mate (Ilex paraguariensis) e saúde: um estudo no metabolismo ósseo e sistema cardiovascular em mulheres pós-menopausa
(Universidade Federal de Santa Maria, 2018-07-05)
Menopause is an event characterized by the complete cessation of menstrual cycles as a
consequence of the important reduction of serum estrogen levels, which leads to increased
chronic diseases (osteoporosis, coronary ...
Uso da combinação de cetamina e metadona no tratamento da dor neuropática causada por diferentes etiologias clínicas
(Universidade Federal de Santa Maria, 2013-04-27)
Methadone and ketamine have been used in neuropathic pain management, but the benefits of the association of both drugs are uncertain. Aiming to enhance the analgesic efficacy and to reduce the occurrence of adverse-effects, ...
Potencial antidepressivo e analgésico do 2-(3,4-dimetoxi-fenil)-4,5-diidro-1H-imidazol (2-DMPI) em camundongos
(Universidade Federal de Santa Maria, 2012-12-18)
Depression and chronic pain coexist in several patients and may be modulated by the same neurotransmitter systems. In this context, various studies have demonstrated that antidepressants from the class of the inhibitors ...
Efeito protetor da N-acetilcisteína sobre o estresse oxidativo causado pela administração crônica de aspartame em ratos
(Universidade Federal de Santa Maria, 2015-03-12)
This thesis evaluated the N-acetylcysteine effects (150 mg/kg, intraperitoneal) on the
biochemical and oxidative changes caused by the daily oral consumption of aspartame at 40
mg/kg for six weeks by rats. For this ...
Atividade radioprotetora, perfil toxicológico e efeito contra a toxicidade da ciclofosfamida do extrato de tucumã: estudos in vitro e in vivo
(Universidade Federal de Santa Maria, 2020-08-04)
Cancer is a multifactorial disease characterized by loss of control of cell division. Nowadays, it is a serious health problem worldwide, leading to many deaths every year. Current treatments for cancer include radiation ...
Avaliação dos efeitos de curcumina e silimarina sobre a toxicidade induzida por micotoxinas in vitro e in vivo
(Universidade Federal de Santa Maria, 2020-10-08)
Mycotoxins are secondary metabolites produced by fungi and represent a worldwide concern
due to their global distribution and the harmful effects caused by their ingestion. This problem
presents itself in its most dramatic ...