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JM-20 como composto multialvo: avaliação do potencial antioxidante, inibidor de colinesterases e citotoxicidade
(Universidade Federal de Santa Maria, 2020-10-29)
Multi-target compounds have aroused the interest of many researchers. The main characteristic of these substances is the ability to act through different mechanisms of action, a relevant fact in cases of pathologies caused ...
Parâmetros moleculares e bioquímicos sobre a exposição per os aguda e crônica a xenobióticos eletrofílicos em insetos-modelos
(Universidade Federal de Santa Maria, 2020-08-13)
Continuous exposure to small doses of toxic substances elicit changes in the transcriptional profile and function of proteins before causing physical damage to organisms. Toxic effects can appear even after exposure stops. ...
Potencial fitorremediador para cromo de Handroanthus chrysotrichus (Mart. ex DC.) Mattos e Handroanthus heptaphyllus (Vell.) Mattos
(Universidade Federal de Santa Maria, 2020-01-30)
Brazil and the world have been facing serious soil contamination problems in the last decade. Among the numerous contaminants are heavy metals, which in turn may or may not be essential for human and plants development. ...
Aspectos fisiológicos de gramíneas nativas da América do Sul submetidas ao excesso de zinco
(Universidade Federal de Santa Maria, 2020-08-31)
The accumulation of metals in soils such as Zinc (Zn) is observed in vineyards from several countries, including Brazil, in the vineyards of the Rio Grande do Sul campaign. The prolonged use of fungicides containing Zn in ...
Avaliação das toxicidades do suco do fruto de Plinia cauliflora em ratos Wistar
(Universidade Federal de Santa Maria, 2020-12-07)
Plants have always been an essential item for human life, being used as raw material, food, and medicine alike. Even today, with all the developments in medicine, plants are still a fundamental source of solutions. Given ...
Atividade radioprotetora, perfil toxicológico e efeito contra a toxicidade da ciclofosfamida do extrato de tucumã: estudos in vitro e in vivo
(Universidade Federal de Santa Maria, 2020-08-04)
Cancer is a multifactorial disease characterized by loss of control of cell division. Nowadays, it is a serious health problem worldwide, leading to many deaths every year. Current treatments for cancer include radiation ...
Avaliação dos efeitos de curcumina e silimarina sobre a toxicidade induzida por micotoxinas in vitro e in vivo
(Universidade Federal de Santa Maria, 2020-10-08)
Mycotoxins are secondary metabolites produced by fungi and represent a worldwide concern
due to their global distribution and the harmful effects caused by their ingestion. This problem
presents itself in its most dramatic ...
Avaliação da segurança do extrato de erva-baleeira (Cordia verbenacea): estudos de toxicidade oral aguda e de doses repetidas em ratos wistar
(Universidade Federal de Santa Maria, 2022-03-31)
Since ancient times, plants have been the main method used in the search for the treatment and cure of different diseases. Thereby, folk medicine has been the principle for the development of medicines that help in the ...
Efeitos do resveratrol na sinalização purinérgica em camundongos expostos ao alumínio
(Universidade Federal de Santa Maria, 2023-09-12)
Aluminum (Al) is a compound found in nature, and is widely used industrially, which means that humans are exposed to it daily. Due to its ability to cross the blood-brain barrier, it can accumulate in the brain in regions ...
Curva dose-resposta do extrato lipofílico composto por clorofilas e carotenoides da microalga Scenedesmus obliquus: papel oxidativo e envolvimento da sinalização purinérgica
(Universidade Federal de Santa Maria, 2023-09-27)
More and more innovative proposals based on bioactive compounds are being presented to
the public. The use of microalgae, such as the species Scenedesmus obliquus, has played
an interesting role in this regard through ...