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Caenorhabditis elegans como modelo experimental para estudos toxicológicos e farmacológicos dos extratos de Luehea divaricata e Paullinia cupana
(Universidade Federal de Santa Maria, 2016-03-16)
The nematode Caenorhabditis elegans is a valuable tool for toxicological and
pharmacological studies. Despite its simple body, the most part of its genes and signaling
pathways are similar to humans, and alterations in ...
Envolvimento dos sistemas purinérgico, colinérgico e estresse oxidativo nos distúrbios da tireoide: possível efeito protetor da quercetina
(Universidade Federal de Santa Maria, 2017-02-22)
Thyroid hormones modulate the metabolic pathways in the body and have important physiological
functions in the brain and vascular system. Changes in their production or distribution lead to disorders
such as hypothyroidism ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Citral como aditivo na dieta de peixes estuarinos: perfil redox, imunidade inata e parâmetros hepáticos
(Universidade Federal de Santa Maria, 2019-06-27)
Citral is a monoterpenoid that occurs in essential oils of different plant species used in folk medicine, which also showed promising effects when added to fish diets. However, in spite of the numerous biological activities ...
Polimorfismo Ala16ValMnSOD na epilepsia: envolvimento dos marcadores inflamatórios, oxidativos e glicolipídicos
(Universidade Federal de Santa Maria, 2019-08-17)
Epilepsy is a neurological disease that affects around 1% of world population, with neurobiological, neurochemical, cognitive and psychological consequences. Despite of the good prognosis, there is a high proportion of ...
O papel do polimorfismo Ala16Val da Mn-SOD no acidente vascular encefálico crônico: um estudo clínico
(Universidade Federal de Santa Maria, 2019-08-17)
Considered one of the most common neurological diseases, stroke has a high morbidity and mortality, and corresponds to 85% of disease cases. Several factors are involved in disease etiology, such as changes in vascular ...
Efeitos do inseticida permetrina sobre o desenvolvimento de peixes-zebra
(Universidade Federal de Santa Maria, 2019-08-30)
Permethrin (PM) is a Type I synthetic pyrethroid (SP) widely used in crops and especially in domestic environments to control harmful insects. Pyrethroids are considered safe, with low mammalian toxicity. However, studies ...
Avaliação do potencial terapêutico do extrato aquoso de Peumus boldus (boldo) frente à toxicidade induzida por ferro e cobre em diferentes modelos experimentais
(Universidade Federal de Santa Maria, 2018-08-10)
The transition metals iron (Fe2+) and copper (Cu2+) are vital trace elements due to oxi-reducing
properties. However, the free Fe2+ and Cu2+ accumulation can lead to oxidative stress (OS), by catalisis
the Fenton reaction. ...
Dieta suplementada com disseleneto de difenila atenua as alterações bioquímicas e comportamentais no modelo de hipotireoidismo induzido por metimazol
(Universidade Federal de Santa Maria, 2012-12-14)
Hypothyroidism is a syndrome resulting from decreased production and secretion of triiothyronine (T3) and thyroxine (T4) hormones, frequently diagnosed in women. Clinical and experimental evidence support the association ...
ATP como modulador do sistema purinérgico e inflamação e status redox em pacientes com melanoma
(Universidade Federal de Santa Maria, 2019-09-16)
Melanoma is a type of skin cancer, formed in melanocytes, cells that produce the pigment melanin. The melanocytes of the epidermis are the most common places of melanoma’s origin; however, it can be also developed in ...